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Levoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalIn vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. … Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer.
Categories: Vitamin B Complex, Heterocyclic Compounds, 2-RingSynonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, L-LeucovorinRilapladib
go.drugbank.com/drugs/DB05119InvestigationalIt is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2 is an enzyme associated with the formation of atherosclerotic plaques.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDapoxetine
go.drugbank.com/drugs/DB04884InvestigationalIn a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. … Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
Mixtures: TADA PLUS 30/20 MG FILM KAPLI TABLET ,4 ADET, TADA PLUS 30/20 MG FILM KAPLI TABLET ,8 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsOctisalate
go.drugbank.com/drugs/DB11062ApprovedOctyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm. It is an ester of salicylic acid and 2-ethylhexanol. … Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters.
Mixtures: Derma Geek Nourishing Facial Moisturizer with Sunscreen Broad Spectrum SPF 30, City Sunscreen Serum SPF 30 Doctor Ts Super goopCategories: Compounds used in a research, industrial, or household settingHepatocyte nuclear factor 4-gamma
go.drugbank.com/bio_entities/BE0003179TargetHumansTranscription factor. Has a lower transcription activation potential than HNF4-alpha
Synonyms: Nuclear receptor subfamily 2 group A member 2Pirlindole
go.drugbank.com/drugs/DB09244ExperimentalPirlindole's efficacy and safety have also been shown in the treatment of fibromyalgia. … This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA drug). It was developed and is currently used as an antidepressant in Russia.
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT1A Receptor AntagonistsSynonyms: 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino(3,2,1-jk)carbazoleSurotomycin
go.drugbank.com/drugs/DB12076InvestigationalSurotomycin, given orally, has been shown to be highly effective against both initial and relapsing hamster Clostridium difficile-associated diarrhea, with a potency similar to vancomycin. … Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection.
Mediator of RNA polymerase II transcription subunit 1
go.drugbank.com/bio_entities/BE0004382TargetHumansMediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Synonyms: Thyroid receptor-interacting protein 2, Peroxisome proliferator-activated receptor-binding proteinNisoxetine
go.drugbank.com/drugs/DB09186ExperimentalIt has been used to research obesity and energy balance, and exerts some local analgesia effects. … Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s.
Betaprodine
go.drugbank.com/drugs/DB01473ExperimentalIllicitIt has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)