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Vepdegestrant
go.drugbank.com/drugs/DB19006ApprovedInvestigationalfulvestrant], which has historically been a standard of care for these advanced breast cancers. … Vepdegestrant is a potent, selective, and orally bioavailable PROteolysis TArgeting Chimera (PROTAC) small molecule estrogen receptor (ER) degrader.
Synonyms: 2,6-piperidinedione, 3-(1,3-dihydro-1-oxo-5-(4-((1-(4-((1r,2s)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl)phenyl)-4-piperidinyl)methyl)-1-piperazinyl)-2h-isoindol-2-yl)-, (3s)-Categories: Selective Estrogen Receptor Degraders, P-glycoprotein inhibitorsFinasteride
go.drugbank.com/drugs/DB01216ApprovedInvestigationalIt works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. … Finasteride is a synthetic 4-azasteroid compound [L10565] and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone
Synonyms: (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamideMixtures: Finasteride 0.1% / Minoxidil 7%, Finasteride 0.1% / Minoxidil 5%Tocilizumab
go.drugbank.com/drugs/DB06273ApprovedInvestigationalTocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. … Two biosimilar versions of tocilizumab have since been approved by the FDA: tocilizumab-bavi, in September 2023,[L48385] and Tyenne® (tocilizumab), in June 2024.
Categories: Interleukin-6 Receptor Antagonist, Cytochrome P-450 CYP3A InducersProducts: ACTEMRA 80 MG/4 ML IV INFUZYONLUK COZELTI KONSANTRESI İÇEREN FLAKON, 1 ADET, ACTEMRA 80 MG/4 ML IV INFUZYONLUK COZELTI KONSANTRESI İÇEREN FLAKON, 4 ADETButalbital
go.drugbank.com/drugs/DB00241ApprovedIllicitThere have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines [A177754] thus it is not indicated for such condition. … Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group.
Synonyms: 5-allyl-5-(2'-methyl-n-propyl) barbituric acid, 5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trioneMixtures: Fiorinal-C 1/4, Fiorinal-C 1/2Dronedarone
go.drugbank.com/drugs/DB04855ApprovedInvestigationalA safety concern for the risk of drug-induced hepatocellular injury has been issued following marketing of dronedarone.[L8800] … [T28] Commonly marketed as Multaq®, dronedarone was approved by the FDA in July 2009 and Health Canada in August 2009.
Synonyms: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide, N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamideCategories: Adrenergic alpha-1 Receptor Antagonists, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexHomosalate
go.drugbank.com/drugs/DB11064ApprovedIt is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. … It is a common ingredient in many commercially available sunscreens. There are no reported adverse effects from homosalate.
Synonyms: 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoateMixtures: Derma Geek Nourishing Facial Moisturizer with Sunscreen Broad Spectrum SPF 30, City Sunscreen Serum SPF 30 Doctor Ts Super goopGuvacine
go.drugbank.com/drugs/DB08848ExperimentalCurrently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant affinity at GABA receptors. … Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication.
Categories: Heterocyclic Compounds, 1-RingWIN 55212-2
go.drugbank.com/drugs/DB13950ExperimentalIt is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of neuropathic pain. It activates p42 and p44 MAP kinase via receptor-mediated signaling. … WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical
Synonyms: (2,3-Dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonateSalts: WIN 55212-2 mesylateUrelumab
go.drugbank.com/drugs/DB12077InvestigationalUrelumab has been used in trials studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and Cancer - Solid Tumors and B-Cell Non-Hodgkin's Lymphoma. … Urelumab is a fully human antibody that targets CD137.
Geneticin
go.drugbank.com/drugs/DB04263ExperimentalResistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II.