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Displaying results 4321 - 4330 of 10000 in total
  1. Drug

    Sildenafil

    go.drugbank.com/drugs/DB00203
    ApprovedInvestigational

    Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in … In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850

    Synonyms: 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazineMixtures: DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET, DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLET
  2. Drug

    Ceftriaxone

    go.drugbank.com/drugs/DB01212
    ApprovedInvestigational

    Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. … [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627].

    Mixtures: CEFTRIAXONA 1000 MG + SULBACTAM 500 MG, CEF-3 INJECTION IM (1G)Categories: Heterocyclic Compounds, 2-Ring, P-glycoprotein inhibitors
  3. Drug

    Paliperidone

    go.drugbank.com/drugs/DB01267
    ApprovedInvestigational

    It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. … Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug.

    Synonyms: 9-hydroxyrisperidoneCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  4. Drug

    Certolizumab pegol

    go.drugbank.com/drugs/DB08904
    ApprovedInvestigational

    [A176606] It was developed and manufactured by UCB Pharma, first FDA approved in 2008[L45018] and updated for a new indication on March 28, 2019.[L5819] … [A176585] It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region.

    Products: CİMZİA 200 MG/ML S.C. ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR (2 ADET), CIMZIA 200 MG
  5. Drug

    Romosozumab

    go.drugbank.com/drugs/DB11866
    ApprovedInvestigational

    In a comparison study of post menopausal women with osteoporosis and a past fracture, romosozumab for 12 months followed by alendronic acid for 12 months was superior to alendronic acid alone for 24 months … Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant

    Products: EVENİTY 105 MG/1,17 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 2 ADET, EVENITY® 90MG/ML
  6. Drug

    Hyaluronic acid

    go.drugbank.com/drugs/DB08818
    ApprovedInvestigationalVet approved

    A popular use of hyaluronic acid in recent years is cosmetic injection due to its ability to minimize the appearance of wrinkles and aging-related skin imperfections.[L32193]

    Mixtures: Calcipotriene 0.005% / Diclofenac Sodium 3% / Hyaluronic Acid Sodium Salt 2% / Niacinamide 2%, Hyaluronic Acid 60mg and Lidocaine 2% PFCategories: Compounds used in a research, industrial, or household setting
  7. Drug

    Epigallocatechin gallate

    go.drugbank.com/drugs/DB12116
    Investigational

    Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy.

    Synonyms: BENZOIC ACID, 3,4,5-TRIHYDROXY-, (2R,3R)-3,4-DIHYDRO-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-2H-1-BENZOPYRAN-3-YL ESTER, (-)-EPIGALLOCATECHIN-3-O-GALLATECategories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 1-Ring
  8. Drug

    Clervonafusp alfa

    go.drugbank.com/drugs/DB17623
    Investigational

    Synonyms: Immunoglobulin g1-kappa, cell-penetrating humanized fab fragment targeting the equilibrative nucleoside transporter 2 (ent2), fused with a human lysosomal .alpha.-glucosidase fragment, glycoform alfa, Immunoglobulin g1, (humanized monoclonal 3e10 .gamma.1-chain fab fragment) fusion protein with 67-952-lysosomal .alpha.
  9. Drug

    Ozekibart

    go.drugbank.com/drugs/DB18675
    Investigational

    Ozekibart is a tetravalent recombinant humanized IgG1 agonist antibody targeting the human TRAIL death receptor 5 (DR5). It is being investigated for the treatment of chondrosarcoma.

    Synonyms: Immunoglobulin, anti-(human death receptor 5) (human-Lama glama clone IF5 single-domain VHH fragment) fusion protein with peptide linker (GGS)2 fusion protein with immunoglobulin anti-(human death receptor, 5) (human-Lama glama clone IF5 single-domain VHH
  10. Drug

    Efepoetin alfa

    go.drugbank.com/drugs/DB19197
    Investigational

    Efepoetin alfa is under investigation in clinical trial NCT04155125 (A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient).

    Synonyms: Human erythropoietin (epoetin alfa) fused to a hybrid human immunoglobulin (ig), consisting of the fc fragment of the igg4 fused to the hinge and amino-terminus of the igd heavy chain isotype 2, produced