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Gedatolisib
go.drugbank.com/drugs/DB11896ApprovedInvestigationalbreast cancer without a PIK3CA mutation detected, following progression on or after at least one line of endocrine therapy in the metastatic setting. … [L63796,L63927] The PI3K/AKT/mTOR pathway is a long-standing target in the breast cancer setting, with previously approved agents acting on a single node of it (i.e. PI3Kα, AKT, or mTORC1).
Phenylethyl alcohol
go.drugbank.com/drugs/DB02192InvestigationalAn antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
Categories: Compounds used in a research, industrial, or household settingPropentofylline
go.drugbank.com/drugs/DB06479ExperimentalCategories: Compounds used in a research, industrial, or household settingIsoxsuprine
go.drugbank.com/drugs/DB08941ApprovedWithdrawnIts vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
Bromodiphenhydramine
go.drugbank.com/drugs/DB01237ApprovedEthanolamine antihistamines produce marked sedation in most patients. … Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies.
Synonyms: 2-(p-bromo-α-phenylbenzyloxy)-N,N-dimethylethylamineThiamine pyrophosphokinase 1
go.drugbank.com/bio_entities/BE0000157TargetEnzymeHumansCatalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism (PubMed:38547260). By producing thiamine pyrophosphate, a cofactor of the mitoc...
Synonyms: Placental protein 20De Novo Triacylglycerol Biosynthesis TG(20:1(11Z)/20:0/20:1(11Z))
smpdb.ca/view/SMP0022630MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
Phosphatidylethanolamine Biosynthesis PE(20:4(5Z,8Z,11Z,14Z)-OH(20)/20:0)
smpdb.ca/view/SMP0127467MetabolicPhosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...
Cardiolipin Biosynthesis CL(11:0/20:0/i-20:0/i-20:0)
smpdb.ca/view/SMP0185533MetabolicCardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition.
Cardiolipin Biosynthesis CL(14:0/20:0/i-20:0/i-20:0)
smpdb.ca/view/SMP0201641MetabolicCardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition.