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CYT-6091
go.drugbank.com/drugs/DB05991ExperimentalCYT-6091 (Aurimune) is an investigational small molecule made up of recombinant human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol bound to the surface of 27 nm colloidal gold particles. It was under investagtio...
Categories: Compounds used in a research, industrial, or household settingIntegrin beta-2
go.drugbank.com/bio_entities/BE0001041TargetHumansIntegrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). … Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).
Synonyms: Complement receptor C3 subunit betaSialic acid-binding Ig-like lectin 7
go.drugbank.com/bio_entities/BE0001648TargetHumansIn the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through
Synonyms: Adhesion inhibitory receptor molecule 1GTP-binding nuclear protein Ran
go.drugbank.com/bio_entities/BE0004559TargetHumansGTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, Pu...
Synonyms: Androgen receptor-associated protein 24Nelotanserin
go.drugbank.com/drugs/DB12555InvestigationalIt is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sleep, the most restorative phase of the sleep cycle, without sacrificing REM or dream sleep. … Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder.
Categories: Heterocyclic Compounds, 1-RingGPI-1485
go.drugbank.com/drugs/DB05814InvestigationalGPI 1485 is a product candidate that belongs to a class of small molecule compounds called neuroimmunophilin ligands. … In preclinical experiments, neuroimmunophilin ligands have been shown to repair and regenerate damaged nerves without affecting normal, healthy nerves.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsFM-VP4
go.drugbank.com/drugs/DB05449InvestigationalFM-VP4 has been shown to inhibit cholesterol absorption and to lower plasma LDL-cholesterol and total cholesterol in a broad range of animal species. … FM-VP4, is a novel hydrophilic phytostanol analogue representing a new class in cholesterol-lowering drugs called cholesterol absorption inhibitors.
Felypressin
go.drugbank.com/drugs/DB00093InvestigationalIt is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth … A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two
Mixtures: PRESTIGE® NF, PRICANEST 3% FELIPRESINACARPULESSynonyms: 2-(L-phenylalanine)-8-L-lysinevasopressin, PLV-2ND7001
go.drugbank.com/drugs/DB05142ExperimentalIt is the first representative of a new generation of psycho-active compounds potentially devoid of several problems seen with existing treatments. … ND7001, a selective PDE2 inhibitor is in clinical trials for the treatment of depression. ND7001 is a solid.
Cirazoline
go.drugbank.com/drugs/DB09202ExperimentalCirazoline acts on a number of α adrenergic receptors. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. … Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.
Categories: Adrenergic alpha-1 Receptor Agonists, Heterocyclic Compounds, 1-Ring