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Navitoclax
go.drugbank.com/drugs/DB12340InvestigationalNavitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer. … Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies,
Synonyms: (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-TrifluoromethanesulfonylbenzenesulfonamideAlvespimycin
go.drugbank.com/drugs/DB12442InvestigationalAlvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. It has been used in trials studying the treatment of solid tumor in various cancer as an antitumor agent.
Large ribosomal subunit protein uL16
go.drugbank.com/bio_entities/BE0009104TargetHumansComponent of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788)
Synonyms: Laminin receptor homologNM-702
go.drugbank.com/drugs/DB05505InvestigationalIn the USA, a Phase 2 study for intermittent claudication caused by arteriosclerosis obliterans has been successfully completed. … Nissan Chemical and Taisho have been jointly developing NM-702, a drug for the treatment of arteriosclerosis obliterans.
Categories: Heterocyclic Compounds, 1-RingOctacosanol
go.drugbank.com/drugs/DB11220InvestigationalNutraceuticalIt has been studied as a potential therapeutic agent for the treatment of Parkinson's disease. … 1-octacosanol is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement.
Synonyms: 1-Octacosanol, n-octacosanolProducts: EUROBIO® CHOLENOL SOFT CAPSULEARX201
go.drugbank.com/drugs/DB05082InvestigationalARX201 (PEG-ahGH) is a recombinant form of human growth hormone that has been modified using Ambrx’s patented ReCODE™ technology to achieve precise spatial positioning of the site of polyethylene glycol … (PEG) attachment to human growth hormone, by biosynthetic incorporation of a chemically unique amino acid (ahGH).
Gremlin-1
go.drugbank.com/bio_entities/BE0011799TargetHumansCytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 ...
Synonyms: Cell proliferation-inducing gene 2 proteinIntegrin alpha-2
go.drugbank.com/bio_entities/BE0012664TargetHumansIntegrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. … It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix
Synonyms: Collagen receptorCobamamide
go.drugbank.com/drugs/DB11191ApprovedNutraceuticalThere has been a shift in the treatment of vitamin B12 deficiency such that MeCbl is being extensively used and promoted. … This drug is available as a nutritional supplement to prevent vitamin B12 deficiency. Vitamin B12 is a collective term for these variously substituted corrinoids.
Synonyms: 5'-Deoxy-5'-adenosylcobalamin, Coenzyme B-12Categories: Vitamin B Complex, Heterocyclic Compounds, 1-RingBebtelovimab
go.drugbank.com/drugs/DB16755ApprovedWithdrawnIt binds to a portion of the SARS-CoV-2 spike (S) protein's receptor-binding domain, thereby preventing spike protein interaction with ACE2 and subsequent viral entry into host cells. … [A245353] This is in contrast to previously developed COVID-19 monoclonal antibody treatments - including [bamlanivimab], [etesevimab], [casirivimab], and [imdevimab] - which have been found ineffective