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Baricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigational[A248400] The EC later approved baricitinib for the treatment of atopic dermatitis, making it the first JAK inhibitor used for this indication in Europe. … [L41760] Baricitinib was first approved by the European Commission (EC) in February 2017 for the treatment of rheumatoid arthritis in adults [A248395] and was later approved by the FDA in 2018.
Ursodeoxycholic acid
go.drugbank.com/drugs/DB01586ApprovedInvestigational[A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary biliary cirrhosis in 1996. … [A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.
Products: ACIDO URSODESOSSICOLICO EG, ACIDO URSODESOSSICOLICO EG STADALacosamide
go.drugbank.com/drugs/DB06218ApprovedInvestigational[A262681] Lacosamide was first approved by the European Commission in August 2008 and was later approved by the FDA in October 2008. … [A262681] It was granted approval by Health Canada in September 2010.[L49206]
Synonyms: (R)-2-acetamido-N-benzyl-3- methoxypropionamide, (+)-(2R)-2-(ACETYLAMINO)-N-BENZYL-3-METHOXYPROPANAMIDEProducts: LACOSAMIDE EG, LASOMID INTetryzoline
go.drugbank.com/drugs/DB06764Approved[L32584, L32589, L32594] It is also used in combination with other drug classes, such as antihistamines, corticosteroids, and glucocorticoids in other countries. … Tetryzoline is found in a wide array of over-the-counter eye drops, including the most common brand, Visine.
Mixtures: OCTILIA ALLERGIA E INFIAMMAZIONE, OCTILIA ALLERGIA E INFIAMMAZIONECategories: Compounds used in a research, industrial, or household settingPseudoephedrine
go.drugbank.com/drugs/DB00852Approved[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. … [A188823] The decongestant effect of pseudoephedrine was described in dogs in 1927.[A188823]
Mixtures: COUGH-EN LINCTUS, COUGH-EN LINCTUSProducts: DEKOFERIN-EX SURUP 150 MLClonazepam
go.drugbank.com/drugs/DB01068ApprovedIllicitInvestigational[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history … in the treatment of the aforementioned medical conditions.
Synonyms: 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one, 5-(2-chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-oneProducts: CLONAZEPAM EGParoxetine
go.drugbank.com/drugs/DB00715ApprovedInvestigational[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. … [T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.
Products: PAROXETINA EG, PAROXETINA EG STADAButriptyline
go.drugbank.com/drugs/DB09016ApprovedWithdrawnButriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.
Dexibuprofen
go.drugbank.com/drugs/DB09213ApprovedWithdrawnIt is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. … Dexibuprofen has a slower dissolution rate in the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability [A19259].
Products: Eu-Med 200 mg SchmerztablettenBrimonidine
go.drugbank.com/drugs/DB00484ApprovedInvestigationalin glaucoma. … Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996.
Mixtures: BRIMONIDINA E TIMOLOLO EG, BRIMONIDINA E TIMOLOLO EGCategories: Sympathomimetics in Glaucoma Therapy