Tetryzoline is an alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion. Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties.
- Mechanism
- Curator reviewed · 3 references
Adrenergic receptors are G-protein-coupled receptors (GPCR) that regulate vascular tone: stimulation of alpha-1 adrenergic receptors leads to vasoconstriction. Ocular redness and nasal congestion often result from vasodilation of nasal, conjunctival, and corneal capillary blood vessels. Activation of alpha-1 adrenergic receptors have been therefore associated with a reduction of symptoms of ocular irritation and nasal congestion. Tetryzoline is a selective agonist of alpha-1 adrenergic receptors, causing vasoconstriction and alleviating ocular and nasal symptoms.
- Primary indication
- Tetryzoline is indicated for the temporary relief of discomfort and redness of the eye due to minor eye irritations as monotherapy or in combination with other eye lubricants and anti-irritants.Curator reviewed · 53 structured indications
- Formula / weight
- C13H16N2 · 200.285 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1979
- Also known as
- Tetrahydrozoline
- Brand names
Resolves to
BYJAVTDNIXVSPW-UHFFFAOYSA-NSMILESC1CN=C(N1)C1CCCC2=CC=CC=C12What you can answer from here — as of September 23, 2026
Which drugs share a target with Tetryzoline, and which of those have an active Phase 3 trial?
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