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Displaying results 4401 - 4410 of 10000 in total
  1. Target

    Calcium-dependent protein kinase 4

    go.drugbank.com/bio_entities/BE0009256
    TargetPlasmodium falciparum (isolate 3D7)

    Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). Plays a central role in the host erythrocyte...

    Polypeptides: Calcium-dependent protein kinase 4
  2. Target

    Sphingosine 1-phosphate receptor 4

    go.drugbank.com/bio_entities/BE0009882
    TargetHumans

    G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulator...

    Polypeptides: Sphingosine 1-phosphate receptor 4Synonyms: S1P receptor 4, S1P receptor Edg-6
  3. Drug

    Levetiracetam

    go.drugbank.com/drugs/DB01202
    ApprovedInvestigational

    make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions. … Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders.

    Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: 6-UR, KEPPRA 100 MG/ML LSG Z EIN
  4. Drug

    Polyethylene glycol

    go.drugbank.com/drugs/DB09287
    ApprovedInvestigationalVet approved

    [A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule. … PEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation.

    Mixtures: Gavilyte G Tm, LUBTANE %0,4 + %0,3 LUBRİKANT GÖZ DAMLASI, ÇÖZELTİ, 1 ADET, 10 MLCategories: Compounds used in a research, industrial, or household setting, P-glycoprotein inhibitors
  5. Target

    Probable L-ascorbate-6-phosphate lactonase UlaG

    go.drugbank.com/bio_entities/BE0004089
    TargetEscherichia coli (strain K12)

    Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions.

    Polypeptides: Probable L-ascorbate-6-phosphate lactonase UlaGFunction: L-ascorbate 6-phosphate lactonase activity
  6. Target

    Mitogen-activated protein kinase kinase kinase 6

    go.drugbank.com/bio_entities/BE0009469
    TargetHumans

    Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways

    Polypeptides: Mitogen-activated protein kinase kinase kinase 6
  7. Target

    Tumor necrosis factor receptor superfamily member 6

    go.drugbank.com/bio_entities/BE0010463
    TargetHumans

    The secreted isoforms 2 to 6 block apoptosis (in vitro)

    Polypeptides: Tumor necrosis factor receptor superfamily member 6
  8. Target

    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

    go.drugbank.com/bio_entities/BE0014062
    TargetHumans

    Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose

    Polypeptides: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Synonyms: D-fructose-6-phosphate amidotransferase 1, Glutamine:fructose-6-phosphate amidotransferase 1
  9. Target

    T cell receptor beta variable 5-6

    go.drugbank.com/bio_entities/BE0023691
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and ...

    Polypeptides: T cell receptor beta variable 5-6
  10. Drug

    Cinpanemab

    go.drugbank.com/drugs/DB16127
    Investigational

    Cinpanemab is under investigation in clinical trial NCT03318523 (Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Participants With Parkinson's Disease).

    Synonyms: Immunoglobulin g1-lambda, anti-(homo sapiens snca (synuclein alpha, alpha-synuclein, park1, park4, parkinson disease (autosomal dominant, lewy body) 4, non a4 component of amyloid precursor, nacp)), monoclonal, Immunoglobulin g1-lambda, anti-(homo sapiens alpha-synuclein)humanized monoclonal antibody.gamma.1 heavy chain (1-442) (homo sapiens vh (ighv3-25*03 (86%) (ighd)-ighj2*01) (8.10.4) (1-113)-homo sapiens