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Displaying results 4401 - 4410 of 5449 in total
  1. Drug

    ARC183

    go.drugbank.com/drugs/DB05124
    Experimental

    ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity … The key advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short half-life, giving it the potential to be an ideal agent for medical procedures that require rapid

  2. Drug

    Gantenerumab

    go.drugbank.com/drugs/DB12034
    Investigational

    treatments include the related antibodies [aducanumab], which has been granted accelerated FDA approval, along with [bapineuzumab], [crenezumab], [donanemab], [lecanemab], and [solanezumab], which are at … Despite the clear association of Aβ aggregation with AD, treatments aimed at preventing Aβ aggregation or removing pre-existing Aβ plaques have shown little to no clinical benefit thus far and remain controversial

  3. Drug

    PlasmaCord

    go.drugbank.com/drugs/DB16363
    Experimental

    [L27581] It is developed by Cellpraxis and is currently being investigated against severe acute respiratory syndrome (SARS).

  4. Drug

    Zodasiran

    go.drugbank.com/drugs/DB17626
    Investigational

    It was granted an orphan drug designation for the treatment of homozygous familial hypercholesterolemia (HoFH).[L45869]

  5. Drug

    Cry5B

    go.drugbank.com/drugs/DB17783
    Experimental

    With demonstrated anthelmintic properties, it has been investigated in the treatment of parasitic intestinal infections.[A259372, A259377]

  6. Drug

    BT200

    go.drugbank.com/drugs/DB18333
    Investigational

    [A261491] It is under investigation for the treatment of von Willebrand disease and hemophilia A.[L48156]

  7. Drug

    AVR-RD-04

    go.drugbank.com/drugs/DB18644
    Experimental

    It consists of autologous CD34+ enriched cells transduced with a lentiviral vector containing RNA resulting in codon-optimized cDNA encoding for functional human cystinosin.

  8. Drug

    BGT-DTDS

    go.drugbank.com/drugs/DB18664
    Experimental

    It is under investigation for the treatment of dopamine transporter deficiency syndrome (DTDS).

  9. Drug

    Bleomycin A6

    go.drugbank.com/drugs/DB12992
    Investigational

    It was developed in China as an antineoplastic antibiotic. This drug participated in clinical trials for the treatment of Squamous Cell Lung Cancer. … It was shown that besides the antitumor effect, Bleomycin A6 had the ability to alter the tumor microenvironment and could contribute toward lung cancer relapse and metastasis on long-term treatment.

  10. Drug

    R-30490

    go.drugbank.com/drugs/DB09179
    Experimental

    It was first synthesized by Janssen Pharmaceutica as part of a structure-activity relationship study of fentanly and its derivatives. … R-30490 was found to be the most selective agonist for the mu opioid receptor out of all the fentanyl analogues tested, but it has never been introduced for medical use in humans, although the closely