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Carmofur
go.drugbank.com/drugs/DB09010ApprovedWithdrawnCarmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
Droxidopa
go.drugbank.com/drugs/DB06262ApprovedInvestigationalThe racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. … Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S.
Categories: Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-2 Receptor AgonistsSorbitol
go.drugbank.com/drugs/DB01638ApprovedInvestigationalA polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. … It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
Sesame oil
go.drugbank.com/drugs/DB11172ApprovedNutraceuticalSesame oil is reported to possess antioxidant, antiaging, antihypertensive, immunoregulatory and anticancer properties. It has also shown to accelerate alcohol decomposition in the liver [A27257]. … Sesame oil is considered an indirect additive used in food cotact substances by the FDA.
Cefotetan
go.drugbank.com/drugs/DB01330ApprovedInvestigationalThe drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Ornithine
go.drugbank.com/drugs/DB00129ApprovedInvestigationalNutraceuticalProduced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine. … L-Ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine.
Mixtures: AMINOPLASMAL-5% E INFUSION, AMINOPLASMAL-10% E INFUSIONProducts: HEPA-MERZ CONCENTRADO DE INFUSIÓNAjmaline
go.drugbank.com/drugs/DB01426ApprovedWithdrawnIt has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope. … The drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular tachycardias.
Gramicidin D
go.drugbank.com/drugs/DB00027ApprovedInvestigationalGramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. … Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus
Lumefantrine co-artemether
go.drugbank.com/drugs/DB13085ApprovedInvestigationalWithdrawnThe exact mechanism of action of lumefantrine is not well defined, but it is thought to inhibit -hematin formation, an important detoxification pathway for the parasite. … falciparum malaria that is resistant to other antimalarials.
Arbaclofen Placarbil
go.drugbank.com/drugs/DB08892InvestigationalArbaclofen Placerbil is a prodrug of Arbaclofen, which is a selective gamma-amino-butyric acid type B receptor agonist and the R-enantiomer of baclofen. … On May 20th, 2013, XenoPort announced plans to terminate the development of Arbaclofen Placerbil for the treatment of multiple sclerosis.
Categories: GABA-B Receptor Agonists