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AICA ribonucleotide
go.drugbank.com/drugs/DB01700InvestigationalAICAR has been used clinically to treat and protect against cardiac ischemic injury. … 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, 1-(5'-phosphoribosyl)-5-amino-4-imidazolecarboxamideVitex agnus-castus fruit extract
go.drugbank.com/drugs/DB13193Investigationalμ (mu) - and δ (delta) -opioid receptors. … The main mechanism of action of vitex agnus-castus fruit extract has not been fully elucidated, however it is suggested to modulate the stress-induced prolactin secretion via dopaminergic actions, and
Davunetide
go.drugbank.com/drugs/DB12613InvestigationalDavunetide is derived from a naturally occurring neuroprotective brain protein known as activity dependent neuroprotective protein. … Davunetide has been used in trials studying the treatment of Progressive Nonfluent Aphasia, Progressive Supranuclear Palsy, Predicted Tauopathies, Including, Corticobasal Degeneration Syndrome, and Frontotemporal
Ceftiofur
go.drugbank.com/drugs/DB11485ExperimentalVet approvedE. coli strains resistant to ceftiofur have been reported. … Ceftiofur is a third generation cephalosporin antibiotic, first described in 1987, and now used in veterinary medicine.
Categories: Heterocyclic Compounds, 2-RingLedipasvir
go.drugbank.com/drugs/DB09027ApprovedSince 2014, ledipasvir has been available as a fixed dose combination product with [sofosbuvir] (tradename Harvoni) used for the treatment of chronic Hepatitis C. … When combined together, ledipasvir and sofosbuvir as the combination product Harvoni has been shown to achieve a SVR between 93 and 99% after 12 weeks of treatment [FDA Label].
Mixtures: HARVONI®Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMitochondrial potassium channel ATP-binding subunit
go.drugbank.com/bio_entities/BE0003673TransporterHumansATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochon...
Synonyms: Mitochondrial sulfonylurea-receptorInterferon Gamma
go.drugbank.com/drugs/DB15753InvestigationalInterferon gamma is a Type 1 inflammatory cytokine and the only type II interferon. It has antitumor properties, antiviral activities, and important immunoregulatory functions. … The interferon is primarily produced by activated T lymphocytes and natural killer cells.
Synonyms: IFN-G, IFN-γGinsenoside Rg1
go.drugbank.com/drugs/DB06750ExperimentalNutraceuticalGinsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). … Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginseng's efficacy.
Synonyms: Panaxoside ATST10088
go.drugbank.com/drugs/DB05151ExperimentalTST10088 has been designed and engineered by Twinstrand to contain a peptide switch that is specifically cleaved by the matrix metalloproteinases which are known to be involved in tumor growth and metastasis … TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating proteins.
Briakinumab
go.drugbank.com/drugs/DB05459InvestigationalAs of 2011 drug development for psoriasis has been discontinued in the U.S. and Europe. … Briakinumab is a human anti-IL-12 monoclonal antibody being developed for the treatment of a number of T-cell driven autoimmune diseases.