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Doxycycline
go.drugbank.com/drugs/DB00254ApprovedInvestigationalVet approvedDoxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline].[L42880] It is a second-generation tetracycline that was first discovered in 1967. … [A174034] Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.[A251730]
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: 5-hydroxy-α-6-deoxytetracycline, 6-alpha-deoxy-5-oxytetracyclineIvermectin
go.drugbank.com/drugs/DB00602ApprovedInvestigationalVet approved(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). … [L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de
Mixtures: Heartgard Plus Chewable Tablet for Dogs - 26 - 50 lbs, Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbsCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNimesulide
go.drugbank.com/drugs/DB04743ApprovedWithdrawnNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.
Mixtures: FRENAG PLUS %1+%5 SPREY, 50 ML, ETNA COMBO 100 MG/8 MG TABLET, 14 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesEstriol
go.drugbank.com/drugs/DB04573ApprovedInvestigationalVet approvedA hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. … It is however available in the United States by prescription filled only by compounding pharmacies.
Mixtures: GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 6 ADET, GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 12 ADETCategories: P-glycoprotein inducers, P-glycoprotein substratesClotrimazole
go.drugbank.com/drugs/DB00257ApprovedInvestigationalVet approvedThis drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. … As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094].
Mixtures: Imazol duo 10 mg/g + 2,5 mg/g Creme, MYKOFUNGIN 3 200MG+10MG/GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersLormetazepam
go.drugbank.com/drugs/DB13872ApprovedIt is marketed by Auden Mckenzie (Pharma Division) in 0.5 and 1 mg tablet formulations.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-oneDimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalIt is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … [L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide
Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: DIMETILFUMARATO EG, DIFUMY-MS®240 MG CÁPSULAS DURAQuinapril
go.drugbank.com/drugs/DB00881ApprovedInvestigational[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423] … [L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.
Mixtures: ACCUZIDE FORT 20 MG/25 MG FILM KAPLI TABLET, 30 ADET, ACCUZIDE 20 MG/12.5 MG FILM TABLET, 30 ADETCategories: Heterocyclic Compounds, 2-RingCetirizine
go.drugbank.com/drugs/DB00341ApprovedInvestigationalOne of the most common uses for this drug is for a condition called _allergic rhinitis_.
Mixtures: ACERADOX® G, Cetirizine HCl and Pseudoephedrine HCl ERCategories: P-glycoprotein inhibitors, P-glycoprotein substratesHydromorphone
go.drugbank.com/drugs/DB00327ApprovedIllicitInvestigationalStructurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. … [A176471] Even though hydromorphone does not present a 6-hydroxyl group, it is categorized under the family of phenanthrenes and it is considered a chemical under the schedule II (medical purposes with
Synonyms: 6-Deoxy-7,8-dihydro-6-oxomorphine, 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates