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Displaying results 441 - 450 of 5504 in total
  1. Drug

    Trastuzumab emtansine

    go.drugbank.com/drugs/DB05773
    ApprovedInvestigational

    Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent … T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-microtubule agent, DM1 (a maytansine derivative)--to produce cell cycle arrest and apoptosis.

    Synonyms: T-DM1Products: KADCYLA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIAL, KADCYLA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 160MG/VIAL
  2. Drug

    Flecainide

    go.drugbank.com/drugs/DB01195
    ApprovedInvestigationalWithdrawn

    [A186931] It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.

    Products: FLECAINIDE EG, FLECADURA 50MG
  3. Drug

    Flutamide

    go.drugbank.com/drugs/DB00499
    ApprovedInvestigational

    An antiandrogen with about the same potency as cyproterone in rodent and canine species.

    Products: FLUTAMIDE EG, Eumide Tablet 250mg
  4. Drug

    Cefaclor

    go.drugbank.com/drugs/DB00833
    ApprovedInvestigational

    Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.

    Products: Dom-cefaclor 250-sus 50mg/ml, PMS-cefaclor 250 - Pws 50mg/ml
  5. Indication

    Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)

    go.drugbank.com/conditions/DBCOND0069581
    Drugs: Ruxolitinib
    Synonyms: Post ET MF, Post-ET MF
  6. Drug

    Azilsartan medoxomil

    go.drugbank.com/drugs/DB08822
    ApprovedInvestigational

    It is used to treat hypertension as monotherapy or in combination with other antihypertensive drugs. It is also available in a combination product with [chlorthalidone]. … It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in February 2011.

    Mixtures: EDARBI CLD® 40MG/12.5MGProducts: EDARBI 20MG TABLETTEN, EDARBI 40MG
  7. Drug

    Irbesartan

    go.drugbank.com/drugs/DB01029
    ApprovedInvestigational

    [L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients not well controlled or not expected to be well controlled on monotherapy.

    Mixtures: APROVASC®150MG/10MG, APROVASC® 300MG/10MGSynonyms: 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
  8. Drug

    Agomelatine

    go.drugbank.com/drugs/DB06594
    ApprovedInvestigational

    Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. … It is currently sold in Australia under the Valdoxan trade name.

    Products: AGOMAVAL 25MG FTA, VALDOXAN 25MG
  9. Drug

    Entecavir

    go.drugbank.com/drugs/DB00442
    ApprovedInvestigational

    It is marketed under the trade name Baraclude (BMS). … It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.

    Products: BARACLUDE 1MG, ENTECAVIR AL 1MG
  10. Drug

    Gentamicin

    go.drugbank.com/drugs/DB00798
    ApprovedInvestigationalVet approved

    [A234349] It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. … [A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity

    Mixtures: GENTAMICINA E BETAMETASONE EG, GENTAMICINA E BETAMETASONE IDIProducts: Gentamicin(e) 120mg Liq IV 1.2mg/ml, Cidomycin Inj 10mg/ml