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Angiopoietin-1 receptor
go.drugbank.com/bio_entities/BE0003379TargetHumansSignaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding … reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.
Synonyms: Tyrosine kinase with Ig and EGF homology domains-2Dehydrocholic acid
go.drugbank.com/drugs/DB11622ApprovedThe use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada. … Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid [A33022]. It has been used for stimulation of biliary lipid secretion.
Categories: Bile Acids and Salts, Cholagogues and CholereticsProducts: Dycholium Tablet 300mgMetamfetamine
go.drugbank.com/drugs/DB01577ApprovedIllicitInvestigationalWithdrawnMethamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. … It is a scheduled drug in most countries due to its high potential for addiction and abuse.
Synonyms: d-N-methylamphetamine, (+)-(S)-N-α-dimethylphenethylamineCategories: Psychostimulants, Agents Used for ADHD and NootropicsPhensuximide
go.drugbank.com/drugs/DB00832ApprovedThe frequency of attacks is reduced by depression of nerve transmission in the motor cortex. … It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures.
MK-3577
go.drugbank.com/drugs/DB14957InvestigationalMK-3577 is under investigation in clinical trial NCT00868790 (A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)).
Anecortave acetate
go.drugbank.com/drugs/DB05288InvestigationalAnecortave acetate (Retaane) is an analog of cortisol acetate; among the modifications to the steroid are the removal of the 11ß hydroxyl OH group and an addition of a 21-acetate group. … As a result of these modifications, anecortave acetate lacks the typical antiinflammatory and immunosuppressive properties of glucocorticoids.Alcon Inc. is developing and marketing Retaane.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsAzimilide
go.drugbank.com/drugs/DB04957InvestigationalIt is not approved for use in any country, but is currently in clinical trials in the United States. … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels.
Categories: Calcium-Regulating Hormones and AgentsPerflubutane
go.drugbank.com/drugs/DB12821ApprovedWithdrawnPerflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. … It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclear stress testing; currently the leading procedure for detecting coronary heart disease.
Categories: Compounds used in a research, industrial, or household settingPegaptanib
go.drugbank.com/drugs/DB04895ApprovedWithdrawnPegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. … Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Categories: Nucleic Acids, Nucleotides, and NucleosidesZalcitabine
go.drugbank.com/drugs/DB00943ApprovedWithdrawnA dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. … The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase.
Categories: Nucleic Acids, Nucleotides, and Nucleosides, Nucleoside and Nucleotide Reverse Transcriptase InhibitorsProducts: ZALCITABINA MK 0.75 MG