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Displaying results 4521 - 4530 of 10000 in total
  1. Target

    Mitogen-activated protein kinase kinase kinase 20

    go.drugbank.com/bio_entities/BE0005595
    TargetHumans

    Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:1183624...

    Synonyms: Human cervical cancer suppressor gene 4 protein
  2. Drug

    Insulin glargine

    go.drugbank.com/drugs/DB00047
    ApprovedInvestigational

    Insulin is typically prescribed later in the course of T2D, after several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient damage has been caused to pancreatic … Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.

    Mixtures: SOLIQUA® 10-40, SOLIQUA® 30-60Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme Inducers
  3. Drug

    Antipain

    go.drugbank.com/drugs/DB15251
    Experimental

    [A214484, A214487] Antipain was used in 2010 to obtain a crystal structure of the _Leishmania major_ oligopeptidase B (OPB), a serine protease that serves as a virulence factor in trypanosomatids. … [A214490] The binding of antipain to OPB has been used in molecular dynamic studies to identify other OPB inhibitors with more favourable pharmacodynamic and pharmacokinetic properties for potential development

  4. Drug

    GTS-21

    go.drugbank.com/drugs/DB05708
    Investigational

    GTS-21 has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated. … GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: DMXB-A, 3-(2,4-dimethoxybenzylidene) anabaseine
  5. Drug

    Tetraethylammonium

    go.drugbank.com/drugs/DB08837
    Investigational

    The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. … The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels.

    Categories: MATE 1 Substrates, MATE 2 Substrates
  6. Drug

    Codeine

    go.drugbank.com/drugs/DB00318
    ApprovedIllicitInvestigational

    The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. … [A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.

    Mixtures: Statuss Green, Fiorinal-C 1/4Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  7. Drug

    Limaprost

    go.drugbank.com/drugs/DB09211
    Investigational

    The drug has been sold under the trade name of Opalmon® Tablets by Ono and Prorenal® Tablets by DSP. … Limaprost alfadex has been shown to improve peripheral circulatory failure with a vasodilator action and an antithrombotic effect.

    Categories: Prostaglandins EProducts: OPALMON TABLETS 5 ug
  8. Drug

    GC-373

    go.drugbank.com/drugs/DB15797
    Experimental

    GC-373 has been shown to inhibit the M<sup>pro</sup> target in various coronavirus strains, including feline, mink, and ferret M<sup>pro</sup> [A219041]. … Along with its prodrug, GC-376, GC-373 was recently investigated _in vitro_ in cell culture against SARS-Cov-2 M<sup>pro</sup> [A219036].

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    CRx-401

    go.drugbank.com/drugs/DB05775
    Experimental

    In third-party clinical studies, the dose of bezafibrate contained in CRx-401 has been observed to have a positive impact on cellular pathways that influence glycemic and lipid profiles, and this dose … It consists of a low dose of the analgesic diflunisal in conjunction with a modified-release therapeutic dose of bezafibrate, an anti-cholesterol agent.

  10. Drug

    Efmoroctocog alfa

    go.drugbank.com/drugs/DB11607
    ApprovedInvestigational

    To date, no confirmed inhibitory autoantibodies were seen in previously treated patients included in clinical studies and treatment-emergent adverse events were generally consistent with those expected … Haemophilia A is a rare bleeding disorder associated with a slow clotting process caused by the deficiency of factor VIII.

    Products: ELOCTATE® 250 UI, ELOCTATE® 500 UI