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Aphidicolin
go.drugbank.com/drugs/DB17742ExperimentalAphidicolin is an antimitotic and antiviral metabolite of the mould _Cephalosporium aphidicola_. It inhibits DNA polymerase alpha and blocks DNA replication.[A259157, A259162]
Synonyms: 9,15-cyclo-c,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3.alpha.,4.alpha.,5.alpha.,17.alpha.)-, 8,11a-methano-11ah-cyclohepta(a)naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3r,4r,4ar,6as,8r,9r,11as,11bs)-Plerixafor
go.drugbank.com/drugs/DB06809ApprovedInvestigational[A7117] Compared to placebo with G-CSF, the plerixafor and G-CSF mobilization regimen has a higher probability of achieving the optimal CD34+ cell target for tandem transplantation in fewer apheresis procedures … Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.
Products: Mozofor 24 mg/1,2 mL S.C. Enjeksiyonluk Çözelti, 1 ADET, Lexeva 24 mg/1,2 mL S.C. Enjeksiyonluk Çözelti, 1 adetCanrenoic acid
go.drugbank.com/drugs/DB09015ApprovedInvestigationalWithdrawnCanrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist. Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
Products: POTASSIO CANRENOATO EG, Aldactone 200 mg/ 10 ml InjektionslösungDolutegravir
go.drugbank.com/drugs/DB08930ApprovedInvestigationalDolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). … [L1035] On November 21, 2017, dolutegravir, in combination with rilpivirine, was approved as part of the first complete treatment regimen with only two drugs for the treatment of adults with HIV-1 named
Mixtures: TRIUMEQ® 50 MG / 600 MG / 300 MG, TRIUMEQ 50 MG/600 MG/300 MG FILM KAPLI TABLET,90 FILM KAPLI TABLETCategories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingLacidipine
go.drugbank.com/drugs/DB09236ApprovedIt is available as once-daily oral tablets containing 2 or 4 mg of the active compound commonly marketed as Lacipil or Motens. It is not currently FDA-approved. … In randomised, well-controlled trials, administration of daily single-dose lacidipine ranging from 2-6 mg demonstrated comparable antihypertensive efficacy similar to that of other long-acting dihydropyridine
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: LACIDIPINA EG, LACIPIL TABLET 4 mgRilpivirine
go.drugbank.com/drugs/DB08864ApprovedInvestigationalRilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients.[A31328] It is a diarylpyrimidine derivative. … [A31329] The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potency and reduces the chance of resistance compared to other NNRTI's
Mixtures: ODEFSEY® 200 MG - 25 MG - 25 MG TABLETAS RECUBIERTAS, ODEFSEY 200 MG/25 MG/25 MG FİLM KAPLI TABLET, 90 ADETCategories: Heterocyclic Compounds, 1-Ring, Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase InhibitorIopamidol
go.drugbank.com/drugs/DB08947ApprovedInvestigationalIopamidol is a contrast agent developed by Bracco with nonionic, low-osmolar properties.
Categories: Compounds used in a research, industrial, or household setting, X-Ray Contrast ActivityProducts: PAMIRAY 370 ENJ. 50 ML 0,755 MG FLAKON, 1 ADET, PAMIRAY 370 ENJ. 100 ML 0,755 MG FLAKON, 1 ADETCoagulation factor VIIa Recombinant Human
go.drugbank.com/drugs/DB00036ApprovedInvestigationalNovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Categories: Increased Coagulation Factor X ActivityProducts: NOVOSEVEN RT 1 MG, NOVOSEVENRT 5 MGDaptomycin
go.drugbank.com/drugs/DB00080ApprovedInvestigational[A231384] Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed daptomycin; it was found that a once-daily dosing … [A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal
Categories: P-glycoprotein substratesProducts: CUBICIN® 350 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, CUBICIN® 500 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLESalicylic acid
go.drugbank.com/drugs/DB00936ApprovedInvestigationalVet approvedA compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions.
Synonyms: 2-Carboxyphenol, O-carboxyphenolInternational brands: Dr. Scholl's Corn Removers, Dr. Scholl's Callus Removers