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SPC2968
go.drugbank.com/drugs/DB06351InvestigationalSPC2968 is a synthetic antisense oligodeoxynucleotide targeting hypoxia-inducible factor-1alpha (HIF-1alpha). It was under investigation in clinical trial NCT02564614 (A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic ...
Toripalimab
go.drugbank.com/drugs/DB15043ApprovedInvestigationalOne mechanism by which this occurs is through the overexpression of programmed cell death ligand (PD-L1)[A261506] - the binding of PD-L1 (and PD-L2) to its target receptor (PD-1) results in the inhibition … of T-cell proliferation and cytokine production, and thus its overexpression can inhibit T-cell-mediated immune surveillance of tumors.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsCynodon dactylon pollen
go.drugbank.com/drugs/DB10351ApprovedIt can be cutaneously, intradermally and subcutaneously administered to initiate an immune response in case of an allergic reaction. … Cynodon dactylon pollen, also known as bermuda grass pollen, is a standardized grass pollen extracts used for the diagnosis and treatment of allergic disease to grass pollen.
Mixtures: Mixture of Standardized and Non-Standardized Southern Grasses, Mixture of Twenty-Two Standardized and Non-Standardized GrassesNitrofural
go.drugbank.com/drugs/DB00336ApprovedVet approvedWithdrawnNitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections.
Categories: Antiseptics and Disinfectants, Blood and Blood Forming OrgansLumiliximab
go.drugbank.com/drugs/DB06162InvestigationalLumiliximab was developed by IDEC Pharmaceuticals, which was acquired by Biogen. Clinical trials for CLL were terminated in 2010, and for allergic asthma in 2007. … Results published from the CLL clinical trial failed to meet primary endpoints.
Categories: Amino Acids, Peptides, and ProteinsEnfuvirtide
go.drugbank.com/drugs/DB00109ApprovedInvestigationalEnfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake … The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting HIV-1 fusion with CD4 cells.
Categories: Amino Acids, Peptides, and ProteinsClobetasone
go.drugbank.com/drugs/DB13158ApprovedClobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions
Categories: clobetasone and antiinfectives, Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: U-CLOSONE CREAM, U-CLOSONE OINTMENTAnecortave acetate
go.drugbank.com/drugs/DB05288InvestigationalAnecortave acetate (Retaane) is an analog of cortisol acetate; among the modifications to the steroid are the removal of the 11ß hydroxyl OH group and an addition of a 21-acetate group. … As a result of these modifications, anecortave acetate lacks the typical antiinflammatory and immunosuppressive properties of glucocorticoids.Alcon Inc. is developing and marketing Retaane.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsTrypan blue free acid
go.drugbank.com/drugs/DB09158ApprovedThis is done to aid in visualization before creating the continuous curvilinear capsulorhexis.