Clobetasone is a corticosteroid used to treat dry eyes, eczema, and dermatitis. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
- Mechanism
- Curator reviewed
Topically applied clobeyasone are thought to bind with cytoplasmic receptors in the dermal and intradermal cells and to induce inhibitory proteins, thus leading to decreased activity of prostaglandins, kinins, histamine, liposomal enzymes and other endogenous mediators of inflammation. Topical corticosteroids inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.
- Primary indication
- In dermatology, topical clobestasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis.Curator reviewed · 20 structured indications
- Formula / weight
- C22H26ClFO4 · 408.89 g/mol (avg)
- First approval
- Canada, 2002
Resolves to
XXIFVOHLGBURIG-OZCCCYNHSA-NSMILES[H][C@]1(C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]2(C)[C@@]1(O)C(=O)CClWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Clobetasone, and which of those have an active Phase 3 trial?
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