Trypan blue

DB09158ApprovedSmall moleculeDiagnostic Dye

Trypan blue is a dye used as a visualizing aid to stain the epiretinal membranes during ophthalmic surgical vitrectomy procedures, thereby facilitating removal of the tissue. Trypan blue is a diazo dye used in ophthalmic cataract surgery to stain the anterior capsule in the presence of a mature cataract.

Mechanism: Trypan blue ophthalmic drops selectively stains membranes in the human eye during posterior surgery, such as epiretinal membranes (ERM) and Internal Limiting Membranes (ILM).
Curator reviewed
Primary indication: Trypan blue is indicated for use as an aid in ophthalmic surgery by staining the epiretinal membranes during ophthalmic surgical vitrectomy procedures, facilitating removal of the tissue.Curator reviewed · 2 structured indications
Formula / weight: C₃₄H₂₈N₆O₁₄S₄ · 872.87 g/mol (avg)
First approval: Canada, 2022 · United States, 2004
Brand names: MembraneBlue
VisionBlue

Resolves to

Compound

UNII768N7QO4KHCAS2538-83-2ChEMBLCHEMBL1089641ChEBI78900PubChem9562061KEGGC19307

Clinical / RWD

RxNorm1726081ATCS01KX02

Structure

InChIKeyZBNARPCCDMHDDV-HVMBLDELSA-NSMILES

CC1=CC(=CC=C1\N=N\C1=C(C=C2C=C(C=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C=C(C=C2C=C1S(O)(=O)=O)S(O)(=O)=O

Targets

P18031PTPN1

What you can answer from here — as of September 21, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

3Marketed productsAcross 2 countries and 2 labellers

1ATC codeIncluding every combination product, plus 15 drug categories

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Trypan blue, and which of those have an active Phase 3 trial?

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