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Displaying results 4541 - 4550 of 10000 in total
  1. Drug

    Gefitinib

    go.drugbank.com/drugs/DB00317
    ApprovedInvestigational

    Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. … Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer.

  2. Drug

    Pipemidic acid

    go.drugbank.com/drugs/DB13823
    Investigational

    Pipemidic acid is a quinolone antibacterial agent with activity against various gram-positive and gram-negative bacteria.[A275138, A275143]

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
  3. Drug

    Octenidine

    go.drugbank.com/drugs/DB12624
    Investigational

    Octenidine is under investigation in clinical trial NCT02697162 (Antiseptic-coated Intermittent Urinary Catheter).

    Categories: Genito Urinary System and Sex Hormones
  4. Drug

    Dexchlorpheniramine maleate

    go.drugbank.com/drugs/DB09555
    Approved

    Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. … Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.

  5. Drug

    Nalorphine

    go.drugbank.com/drugs/DB11490
    ExperimentalVet approved

    Nalorphine is a mixed opioid agonist–antagonist. … It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.

    Categories: Semi-synthetic Opioids
  6. Drug

    Streptozocin

    go.drugbank.com/drugs/DB00428
    ApprovedInvestigational

    An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

    Synonyms: 1-METHYL-1-NITROSO-3-((2R,3R,4S,5R)-3,4,5,6-TETRAHYDROXY-1-OXOHEXAN-2-YL)UREA, 1-METHYL-1-NITROSO-3-((3R,4R,5S,6R)-2,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3-YL)UREA
  7. Drug

    Clofoctol

    go.drugbank.com/drugs/DB13237
    Experimental

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
  8. Drug

    Metrizamide

    go.drugbank.com/drugs/DB01578
    Experimental

    It is also used as a resorbable, non-ionic contrast medium. … Metrizamide is a solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity.

  9. Target

    Baculoviral IAP repeat-containing protein 3

    go.drugbank.com/bio_entities/BE0010674
    TargetHumans

    Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.

    Synonyms: TNFR2-TRAF-signaling complex protein 1
  10. Drug

    KB3305

    go.drugbank.com/drugs/DB06349
    Experimental

    KB3305 is an investigational liver selective antagonist for the glucocorticoid receptor, developed by Karo Bio for the treatment of Type 2 Diabetes.

    Synonyms: (4R)-4-((3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-DIHYDROXY-3-(2-(4-((8S,11R,13S,14S,17S)-17-HYDROXY-13-METHYL-3-OXO-17-PROP-1-YNYL-1,2,6,7,8,11,12,14,15,16-DECAHYDROCYCLOPENTA(A)PHENANTHREN-11-YL)-N-METHYL-ANILINO