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ATP synthase F(0) complex subunit a
go.drugbank.com/bio_entities/BE0009014TargetHumansThese two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). … ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256).
Polypeptides: ATP synthase F(0) complex subunit aSynonyms: Proton-conducting channel, ATP synthase F(0) complex subunit aV-type proton ATPase catalytic subunit A
go.drugbank.com/bio_entities/BE0009200TargetPlasmodium falciparum (isolate 3D7)Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates
Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit AMethocarbamol
go.drugbank.com/drugs/DB00423ApprovedInvestigationalVet approvedMethocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. … [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose that may be combined with [acetaminophen] or [ibuprofen].
Mixtures: SINAXAR ® A TABLETAS, Robaxisal C 1/4Synonyms: (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamateHydrocodone
go.drugbank.com/drugs/DB00956ApprovedIllicitInvestigationalHistorically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. … Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain.
Mixtures: DOXU ® 5/250 MG TABLETA RECUBIERTA, ACETAMINOFEN / HIDROCODONA BITARTRATO 325 MG / 5 MG TABLETASCategories: Heterocyclic Compounds with 4 or More Rings, Cytochrome P-450 SubstratesZiprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigational[A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525] … generally thought to be as efficacious as first generation antipsychotics but differ in their adverse effect profiles.
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsProducts: ZELDOX IM ENJ. SOL. ICIN KURU TOZ ICEREN FLAKON 20MG/ML FLAKON, 1 ADET, GEODON® CAPSULAS 80 MGStage IV Primary Peritoneal Cancer
go.drugbank.com/conditions/DBCOND0030573Drugs: BevacizumabSynonyms: Primary, stage 4 Peritoneal Cancer, Stage 4 Primary Peritoneal CancerKetotifen
go.drugbank.com/drugs/DB00920ApprovedInvestigational[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is … It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].
Categories: Heterocyclic Compounds, 1-RingProducts: KETOTIFENE EG, KETEN SYRUP 1 mg/5 mlAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalAtorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid.
Mixtures: TIAZOMET ® A 40/10 TABLETAS, EZETIMIBE E ATORVASTATINA DOCCategories: P-glycoprotein inhibitors, P-glycoprotein substratesHuman immunoglobulin G
go.drugbank.com/drugs/DB00028ApprovedInvestigationalIntravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. … IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders.
Categories: Immunoglobulin G, Human Immunoglobulin GSynonyms: Human immunoglobulin G, Immunoglobulin G, humanMidodrine
go.drugbank.com/drugs/DB00211ApprovedInvestigationalAn ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Synonyms: (±)-2-amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)acetamide, 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamideCategories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor Agonists