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Rivaroxaban
go.drugbank.com/drugs/DB06228ApprovedInvestigationalHowever there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. … FDA approved on July 1, 2011.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: RIVAROXABAN EG, RIVAROXABAN EG STADAClopidogrel
go.drugbank.com/drugs/DB00758ApprovedInvestigationalClopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. … recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides
Mixtures: KLOGEL-A 75/75 MG KAPSUL, 30 ADET, KLOGEL-A 75/75 MG KAPSUL, 90 ADETCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPleckstrin homology domain-containing family A member 1
go.drugbank.com/bio_entities/BE0003262TargetHumansBinds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane
Polypeptides: Pleckstrin homology domain-containing family A member 1Synonyms: PH domain-containing family A member 1Potassium voltage-gated channel subfamily A member 2
go.drugbank.com/bio_entities/BE0004715TargetHumansIn contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). … Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity)
Polypeptides: Potassium voltage-gated channel subfamily A member 2Potassium voltage-gated channel subfamily A member 3
go.drugbank.com/bio_entities/BE0004716TargetHumansAssuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with
Polypeptides: Potassium voltage-gated channel subfamily A member 3Potassium voltage-gated channel subfamily A member 5
go.drugbank.com/bio_entities/BE0004717TargetHumansMay play a role in regulating the secretion of insulin in normal pancreatic islets … Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity
Polypeptides: Potassium voltage-gated channel subfamily A member 5Potassium voltage-gated channel subfamily A member 6
go.drugbank.com/bio_entities/BE0004718TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (Pu...
Polypeptides: Potassium voltage-gated channel subfamily A member 6Potassium voltage-gated channel subfamily A member 10
go.drugbank.com/bio_entities/BE0004720TargetHumansVoltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the me...
Polypeptides: Potassium voltage-gated channel subfamily A member 10A disintegrin and metalloproteinase with thrombospondin motifs 13
go.drugbank.com/bio_entities/BE0009336EnzymeTargetHumansCleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13C-type lectin domain family 12 member A
go.drugbank.com/bio_entities/BE0010945TargetHumansAlso recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).
Polypeptides: C-type lectin domain family 12 member A