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Displaying results 451 - 460 of 10000 in total
  1. Drug

    Amantadine

    go.drugbank.com/drugs/DB00915
    ApprovedInvestigational

    The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. … An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia.

    Synonyms: 1-adamantanamine, 1-adamantylamineInternational brands: PK-Merz
  2. Drug

    Methoxsalen

    go.drugbank.com/drugs/DB00553
    ApprovedInvestigational

    It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. … A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia.

    Synonyms: O-methylxanthotoxol, 6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactoneCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-Ring
  3. Target

    Histone H2B type 1-C/E/F/G/I

    go.drugbank.com/bio_entities/BE0005156
    TargetHumans

    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA ...

    Polypeptides: Histone H2B type 1-C/E/F/G/I
  4. Drug

    Dimethicone 410

    go.drugbank.com/drugs/DB14005
    Approved

    [L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%. … Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products.[A32462] It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit.

    Products: Infants Relief Non-Staining Formula
  5. Drug

    Megestrol acetate

    go.drugbank.com/drugs/DB00351
    ApprovedInvestigationalVet approved

    As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer. … 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester.

    Synonyms: 17α-Acetoxy-6-dehydro-6-methylprogesterone, 17alpha-Acetoxy-6-dehydro-6-methylprogesteroneCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  6. Drug

    Iron (III) oxide adipate

    go.drugbank.com/drugs/DB16084
    Investigational

    Synonyms: Adipic acid ion (2-), Adipate(2-)
  7. Drug

    L-2-amino-4-methoxy-cis-but-3-enoic acid

    go.drugbank.com/drugs/DB03611
    Experimental

    Synonyms: L-2-amino-4-methoxy-cis-but-3-enoic acid
  8. Drug

    Follitropin

    go.drugbank.com/drugs/DB00066
    ApprovedInvestigational

    Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). … Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.

    Synonyms: FSH-a, FSH-bInternational brands: Cinnal-F
  9. Drug

    Heparin

    go.drugbank.com/drugs/DB01109
    ApprovedInvestigational

    Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate. … Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da.

    Mixtures: BARICUS 50 IU/%1/%10 JEL , 50 G, NOSKAR 100 MG/50 IU/10 MG / G, JEL 120 GProducts: Hep-Lock U/P, HEPARINASODICA USP 25000 UI/5 ML
  10. Indication

    No more than 2 prior chemotherapy regimens

    go.drugbank.com/conditions/DBCOND0128348
    Drugs: Bevacizumab
    Synonyms: No more than 2 prior chemotherapy regimens