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Displaying results 4601 - 4610 of 10000 in total
  1. Drug

    Mepiprazole

    go.drugbank.com/drugs/DB09197
    Experimental

    It acts as a 5-HT2A and α1-adrenergic receptor antagonist, and has also been shown to inhibit the reuptake and induce the release of serotonin, dopamine, and norepinephrine to varying extents. … Mepiprazole mediates a weak inhibitory action on the uptake of 5-HT on hypothalamic neurons [A7816]. Mepiprazole is marketed in Spain for the treatment of anxiety neuroses.

    Categories: Heterocyclic Compounds, 1-Ring
  2. Drug

    SRP 299

    go.drugbank.com/drugs/DB05440
    Experimental

    Mycobacterium vaccae is a non-pathogenic, saprophytic bacteria whose antigens can be used to induce peripheral immune activation through the activity of regulatory T-cells that surpress inappropriate Th2 … A specific subset of serotonergic neurons in the interfascicular part of the dorsal raphe nucleus (DRI) is believed to be involved, based on studies with mice.

  3. Drug

    Propacetamol

    go.drugbank.com/drugs/DB09288
    Investigational

    Propacetamol is a non-opioid analgesic devoid of the major contraindications. … Propacetamol is a parenteral formulation of paracetamol and thus, it is a prodrug that is completely hydrolyzed to paracetamol.

    Categories: Non COX-2 selective NSAIDS, Cytochrome P-450 Substrates
  4. Drug

    Cyclopropane

    go.drugbank.com/drugs/DB13984
    Experimental

    Cyclopropane was initially investigated because it was thought to be the toxic element in ethylene. … Instead, it turned out to be an excellent anesthetic with very rapid onset and recovery while maintaining stable hemodynamics. Its use was ultimately limited because it was highly explosive.

  5. Drug

    Dyphylline

    go.drugbank.com/drugs/DB00651
    ApprovedWithdrawn

    Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

    Synonyms: 7-(β,γ-dihydroxypropyl)theophylline, (1,2-dihydroxy-3-propyl)thiophyllinMixtures: Dy G, Dilex-G 400
  6. Drug

    Medical air

    go.drugbank.com/drugs/DB09337
    ApprovedInvestigationalVet approved

    Medical air is supplied by a special air compressor to patient care areas using clean outside air.

    Mixtures: Carbon Dioxide 1% W Air, Carbon Dioxide 15.1% W Air
  7. Drug

    Atipamezole

    go.drugbank.com/drugs/DB11481
    InvestigationalVet approved

    Atipamezole is a synthetic α2 adrenoceptor antagonistused to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. … It has also been undergone research as a potential anti-Parkinsonian drug for humans.

    Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor Antagonists
  8. Drug

    VP025

    go.drugbank.com/drugs/DB05133
    Experimental

    It is considered to be a systemic anti-inflammatory and neuroprotective agent. … It is being developed to target the chronic inflammation within the central nervous system that is associated with a number of neurological diseases, including Alzheimer’s disease, Parkinson’s disease,

  9. Drug

    Bleselumab

    go.drugbank.com/drugs/DB15253
    Investigational

    Bleselumab is under investigation in clinical trial NCT02921789 (Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney

  10. Drug

    Pyruvic acid

    go.drugbank.com/drugs/DB00119
    ApprovedInvestigationalNutraceutical

    An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures.

    Synonyms: 2-Oxopropansäure, 2-Oxopropionsäure