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Migalastat
go.drugbank.com/drugs/DB05018ApprovedInvestigationalFabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). … have amenable GLA variants.
Categories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological ChaperonesAvelumab
go.drugbank.com/drugs/DB11945ApprovedInvestigationalAvelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalA prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … [L33340] A companion diagnostic device - the VENTANA MMR RxDx Panel - was also approved alongside this indication to select appropriate patients for treatment.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsPeginterferon alfa-2b
go.drugbank.com/drugs/DB00022ApprovedInvestigationalPeginterferon alfa-2b is available as a variable dose injectable product (tradename Pegintron) used for the treatment of chronic Hepatitis C. … Peginterferon alfa-2b was used alongside [DB00811] with the intent to cure, or achieve a sustained virologic response (SVR), after 48 weeks of therapy.
Categories: Compounds used in a research, industrial, or household settingAlanine
go.drugbank.com/drugs/DB00160ApprovedInvestigationalNutraceuticalAlanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination.
Synonyms: L-Alanin, L-alanineMixtures: AA-Ven, Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose InjecProline
go.drugbank.com/drugs/DB00172ApprovedInvestigationalNutraceuticalProline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. … Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.
Synonyms: L-Prolin, L-ProlinaMixtures: AA-Ven, Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose InjecPolymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429].
Mixtures: Pomada De La Campana Triple Antibiotic Pain Relief, Tribioticlc Lc LcGuaifenesin
go.drugbank.com/drugs/DB00874ApprovedInvestigationalVet approvedSince that time the agent has been a combination component of various prescription and non-prescription over-the-counter cough and cold products and is currently a widely available over-the-counter generic … Guaifenesin possesses a storied history, having been originally formally approved by the US FDA in 1952 and continues to be one of very few - if not perhaps the only drug that is readily available and
Mixtures: Entex LA, Entex LAProducts: Siltussin SA, Compresso Ggf 95 SaPariglasgene brecaparvovec
go.drugbank.com/drugs/DB16801Approved[L64050,L64051] It is administered as a single, one-time intravenous infusion. … Pariglasgene brecaparvovec-opnr is an adeno-associated virus serotype 8 (AAV8)–based gene therapy for glycogen storage disease type Ia (GSDIa), a disorder caused by deficiency of the enzyme glucose-6-phosphatase
Camphor
go.drugbank.com/drugs/DB01744ApprovedInvestigationalWithdrawnCamphor is a bicyclic monoterpene ketone found widely in plants, especially _Cinnamomum camphora_. It is used topically as a skin antipruritic and as an anti-infective agent. … When ingested, camphor has a rapid onset of toxic effects, and camphorated oil is the product most often responsible for its toxicity.
Mixtures: Swan Brand Qian Li Zui Fong Yew Liniment, HAI-O QIAN LI ZHUI FENG YOU LINIMENTProducts: Formula A