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Metformin

[A36559] Metformin was first approved in Canada in 1972,[A36552] and received subsequent FDA approval in the US in 1995.[L12207] … It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels.

Celecoxib

[A181532] It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. … [L7604] Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies

Grape seed oil

Grape seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Bromhexine

It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.

Topiramate

[A175249] It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. … [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.[A188330]

Theophylline

Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. … Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.

Allantoin

Allantoin has also demonstrated to ameliorate the wound healing process in some studies [A23498]. … Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label].

Cimetidine

Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output.

Prednisolone

[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]

Anvatabart opadotin