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Enfortumab vedotin
go.drugbank.com/drugs/DB13007ApprovedInvestigational[L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable … The clinical development of enfortumab vedotin was the result of a collaboration between Astellas Pharma and Seattle Genetics [A188868] and it was first approved for use in the United States in December
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PADCEV 20 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ , 1 ADET, PADCEV 30 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ , 1 ADETInsulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalAfrezza does not currently have Health Canada or European Medicines Agency approval for marketing in Canada or the EU. … Due to its quick onset of action, human insulin is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas
Mixtures: INSUMAN COMB 25 100I E/ML, INSUMAN COMB 25 100I E/MLCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersCalcium citrate
go.drugbank.com/drugs/DB11093ApprovedInvestigationalCalcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
Mixtures: Citrate De Calcium Plus Vitamine D Et Zinc, CALCIBON D® 315 MGCategories: Compounds used in a research, industrial, or household setting, ascorbic acid (vit C) and calciumRO-6870810
go.drugbank.com/drugs/DB15151InvestigationalRO-6870810 is under investigation in clinical trial NCT02308761 (A Study of RO6870810/TEN-010 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndrome).
Synonyms: 6H-THIENO(3,2-F)(1,2,4)TRIAZOLO(4,3-A)(1,4)DIAZEPINE-6-ACETAMIDE, 4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-N-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)-, (6S)-, BET INHIBITOR TEN-010Categories: Heterocyclic Compounds, 1-RingOmega-3-acid ethyl esters
go.drugbank.com/drugs/DB09539ApprovedInvestigationaltriglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia[FDA Label][A176687]. … Omega-3-acid ethyl esters are currently marketed in the US, EU, and many other regions under the brand name Lovaza[FDA Label][L5849].
Synonyms: omega-3 acid ethyl esters, Omega-3-acid ethyl estersMixtures: ROSUVASTATINA E OMEGA 3 SPA SOCIET PRODOTTI ANTIBIOTICI, ROSUVASTATINA E OMEGA 3 SPA SOCIET PRODOTTI ANTIBIOTICIPimecrolimus
go.drugbank.com/drugs/DB00337ApprovedInvestigationalIt is currently available as a topic cream used in the treatment of atopic dermatitis (eczema). … Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Elidel 10 mg/g Creme, ELIDEL %1 KREM, 15 GManidipine
go.drugbank.com/drugs/DB09238ApprovedInvestigationalWithdrawnManidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. … It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: MANIDIPINA EG, IPERTEN 20 MG TABLET, 28 ADETEpigallocatechin gallate
go.drugbank.com/drugs/DB12116InvestigationalEpigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy.
Synonyms: BENZOIC ACID, 3,4,5-TRIHYDROXY-, (2R,3R)-3,4-DIHYDRO-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-2H-1-BENZOPYRAN-3-YL ESTER, (-)-EPIGALLOCATECHIN-3-O-GALLATECategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingTeduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.
Synonyms: Gly(2)-GLP-2, (Gly2)GLP-2Categories: Compounds used in a research, industrial, or household setting, Glucagon-like Peptide-2 (GLP-2) AgonistsZaleplon
go.drugbank.com/drugs/DB00962ApprovedIllicitZaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. … Zaleplon is a schedule IV drug in the United States.
Synonyms: 3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilideCategories: Heterocyclic Compounds, 1-Ring, GABA-A Receptor Agonists