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Lovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_.
Synonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneCategories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSodium phosphate, monobasic, unspecified form
go.drugbank.com/drugs/DB14503ApprovedMixtures: Fresh Prep Laxative, Utira-CDoxepin
go.drugbank.com/drugs/DB01142ApprovedInvestigational[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. … [T83] In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PURDOX %5 KREM, 30 G, EXPAN® 50 MGStromal cell-derived factor 1
go.drugbank.com/bio_entities/BE0001150TargetHumansStimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity)
Synonyms: Pre-B cell growth-stimulating factorMigalastat
go.drugbank.com/drugs/DB05018ApprovedInvestigationalmigalastat therapy, Amicus Therapeutics' brand name Galafold was approved using the Accelerated Approval pathway, under which the FDA may approve drugs for serious conditions where there is an unmet medical … Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A).
Categories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones, Heterocyclic Compounds, 1-RingSynonyms: 1-Deoxygalactostatin, 1-DeoxygalactonojirimycinIvermectin
go.drugbank.com/drugs/DB00602ApprovedInvestigationalVet approvedWhile studies are still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and the clinical utility of this data remains unclear. … [L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de
Mixtures: Ivermectin 1% / Metronidazole 1% / Niacinamide 4%, Ivermectin 1% / Metronidazole 1%Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsCorynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10584ApprovedInvestigationalMixtures: -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE, 3 ANTIGENLevomenthol
go.drugbank.com/drugs/DB00825ApprovedInvestigationalMenthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.
Mixtures: TOKUSEN MEDICAL PLASTER, Pishuho Medical PlasterCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDocusate
go.drugbank.com/drugs/DB11089ApprovedInvestigationalStill docusate is available in over-the-counter products as a common laxative. … Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201].
Mixtures: Taron-prex Prenatal, Senna-SProducts: H E B Stool Softener laxative, Doc Q LaceJSM 6427
go.drugbank.com/drugs/DB06139InvestigationalJSM 6427 is the first small molecule alpha5beta1 integrin receptor antagonist of its kind to be developed. It has been biologically validated for therapeutic use in the prevention and treatment of wet AMD, the leading cause of blindness ...