Sodium phosphate, monobasic, unspecified form

Identification

Name
Sodium phosphate, monobasic, unspecified form
Accession Number
DB14503
Description
Not Available
Type
Small Molecule
Groups
Approved
Synonyms
Not Available

Pharmacology

Indication

Used to treat constipation or to clean the bowel before a colonoscopy Label.

Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Sodium phosphate inceases fecal water content to increase mobility through the large intestine 1.

Mechanism of action

Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen 1.

Absorption

Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h 3.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity

Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats 7. Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma 4. Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients 3.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium phosphate, monobasic, unspecified form.
AclidiniumThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium phosphate, monobasic, unspecified form is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Almasilate.
AluminiumThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Aluminium.
Aluminium phosphateThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Aluminium phosphate.
Aluminum hydroxideThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Aluminum hydroxide.
AmantadineThe therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Sodium phosphate, monobasic, unspecified form.
Additional Data Available
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  • Severity
    Severity
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  • Evidence Level
    Evidence Level
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  • Action
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Food Interactions
  • Take with a full glass of water.
  • Take with food.

Products

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Active Moieties
NameKindUNIICASInChI Key
Phosphoric acidunknownE4GA8884NN7664-38-2NBIIXXVUZAFLBC-UHFFFAOYSA-N
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Phosphate ionionicNK08V8K8HR14265-44-2NBIIXXVUZAFLBC-UHFFFAOYSA-K
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Care One EnemaSodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalAmerican Sales Company2010-01-182014-06-07US flag
Curad Oral Saline LaxativeSodium phosphate, monobasic, unspecified form (7.2 g/15mL) + Sodium phosphate, dibasic, unspecified form (2.9 g/15mL)LiquidOralMedline Industries2012-07-162016-12-31US flag
Curad Oral Saline LaxativeSodium phosphate, monobasic, unspecified form (7.2 g/15mL) + Sodium phosphate, dibasic, unspecified form (2.9 g/15mL)LiquidOralMedline Industries2012-07-162016-12-31US flag
Curad Saline LaxativeSodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalMedline Industries, Inc.2012-07-162017-01-01US flag
CVS PharmacySodium phosphate, monobasic, unspecified form (9.5 g/59mL) + Sodium phosphate, dibasic, unspecified form (3.5 g/59mL)EnemaRectalCVS Health2014-05-20Not applicableUS flag
CVS PharmacySodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalCVS PHARMACY2013-03-08Not applicableUS flag
Discount Drug Mart EnemaSodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalDiscount Drug Mart2013-12-27Not applicableUS flag
EnemaSodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalKroger2009-11-072015-04-22US flag
EnemaSodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalMeijer Distribution2009-11-062015-04-01US flag
EnemaSodium phosphate, monobasic, unspecified form (19 g/118mL) + Sodium phosphate, dibasic, unspecified form (7 g/118mL)EnemaRectalMedicine Shoppe International2009-11-202015-04-22US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DarcalmaSodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1) + Phenyl salicylate (36.2 mg/1)TabletOralKylemore Pharmaceuticals, LLC2009-12-012009-12-02US flag
DarcalmaSodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (0.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1) + Phenyl salicylate (36.2 mg/1)TabletOralRiver's Edge Pharmaceuticals, LLC2008-12-222011-07-31US flag
OroMinSodium phosphate, monobasic, unspecified form (0.056 g/100g) + Calcium chloride dihydrate (0.054 g/100g) + Sodium fluoride (0.01 g/100g)RinseDentalGermiphene Corporation2017-06-16Not applicableUS flag
Uro-BLUESodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (0.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1)TabletOralMethod Pharmaceuticals2014-12-012015-07-06US flag
Urogesic BlueSodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (0.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1)TabletOralEdwards Pharmaceuticals, Inc2010-04-302017-12-30US flag
Urogesic BlueSodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (0.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1)Tablet, coatedOralEDWARDS PHARMACEUTICALS, INC.2010-11-19Not applicableUS flag
Urolet MbSodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (0.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1)TabletOralBurel Pharmaceuticals, Llc2015-06-262016-10-23US flag
UtaSodium phosphate, monobasic, unspecified form (40.8 mg/206.92mg) + Hyoscyamine sulfate dihydrate (.12 mg/206.92mg) + Methenamine (120 mg/206.92mg) + Methylene blue trihydrate (10 mg/206.92mg) + Phenyl salicylate (36 mg/206.92mg)CapsuleOralSTEWART-JACKSON PHARMACAL, INC2002-08-012016-03-08US flag
UtaSodium phosphate, monobasic, unspecified form (40.8 mg/170.92mg) + Hyoscyamine sulfate dihydrate (0.12 mg/170.92mg) + Methenamine (120 mg/170.92mg) + Methylene blue trihydrate (10 mg/170.92mg)CapsuleOralSj Pharmaceuticals, Llc2014-09-262019-01-24US flag
Utira-CSodium phosphate, monobasic, unspecified form (40.8 mg/1) + Hyoscyamine sulfate dihydrate (0.12 mg/1) + Methenamine (81.6 mg/1) + Methylene blue trihydrate (10.8 mg/1) + Phenyl salicylate (36.2 mg/1)TabletOralMission Pharmacal Company2011-09-11Not applicableUS flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
3980JIH2SW
CAS number
Not Available

References

General References
  1. Rex DK: Dosing considerations in the use of sodium phosphate bowel preparations for colonoscopy. Ann Pharmacother. 2007 Sep;41(9):1466-75. Epub 2007 Jul 24. [PubMed:17652123]
  2. Schanz S, Kruis W, Mickisch O, Kuppers B, Berg P, Frick B, Heiland G, Huppe D, Schenck B, Horstkotte H, Winkler A: Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial. Diagn Ther Endosc. 2008;2008:713521. doi: 10.1155/2008/713521. [PubMed:18645612]
  3. Ehrenpreis ED: Increased serum phosphate levels and calcium fluxes are seen in smaller individuals after a single dose of sodium phosphate colon cleansing solution: a pharmacokinetic analysis. Aliment Pharmacol Ther. 2009 Jun 1;29(11):1202-11. doi: 10.1111/j.1365-2036.2009.03987.x. Epub 2009 Feb 27. [PubMed:19298584]
  4. Razzaque MS: Phosphate toxicity: new insights into an old problem. Clin Sci (Lond). 2011 Feb;120(3):91-7. doi: 10.1042/CS20100377. [PubMed:20958267]
  5. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [PubMed:23398154]
  6. FDA Guide: Sodium Phosphate Tablet [Link]
  7. ChemIDPlus: Sodium Phosphate [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Unknown StatusTreatmentMalnutrition1
1CompletedNot AvailableHealthy Volunteers1
1CompletedTreatmentType 1 Diabetes Mellitus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral
EnemaRectal16 g/100mL
LiquidRectal
SolutionIntravenous
KitIntravenous
LiquidOral
RinseDental
EnemaRectal
Tablet, coatedOral
CapsuleOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Not Available
Specific Function
Not Available
Gene Name
SLC20A1
Uniprot ID
Q8WUM9
Uniprot Name
Sodium-dependent phosphate transporter 1
Molecular Weight
73699.01 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [PubMed:23398154]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Virus receptor activity
Specific Function
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular m...
Gene Name
SLC20A2
Uniprot ID
Q08357
Uniprot Name
Sodium-dependent phosphate transporter 2
Molecular Weight
70391.755 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [PubMed:23398154]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Sodium:phosphate symporter activity
Specific Function
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
Gene Name
SLC34A1
Uniprot ID
Q06495
Uniprot Name
Sodium-dependent phosphate transport protein 2A
Molecular Weight
68936.53 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [PubMed:23398154]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Sodium:phosphate symporter activity
Specific Function
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the s...
Gene Name
SLC34A2
Uniprot ID
O95436
Uniprot Name
Sodium-dependent phosphate transport protein 2B
Molecular Weight
75758.535 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [PubMed:23398154]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Sodium:phosphate symporter activity
Specific Function
May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.
Gene Name
SLC34A3
Uniprot ID
Q8N130
Uniprot Name
Sodium-dependent phosphate transport protein 2C
Molecular Weight
63548.94 Da
References
  1. Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. [PubMed:12360109]

Drug created on July 11, 2018 11:37 / Updated on June 12, 2020 10:53

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