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Displaying results 481 - 490 of 10000 in total
  1. Drug

    Lovastatin

    go.drugbank.com/drugs/DB00227
    ApprovedInvestigational

    [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSynonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
  2. Drug

    Sodium phosphate, monobasic, unspecified form

    go.drugbank.com/drugs/DB14503
    Approved

    Mixtures: Fresh Prep Laxative, Utira-C
  3. Drug

    Doxepin

    go.drugbank.com/drugs/DB01142
    ApprovedInvestigational

    [T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. … [T83] In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PURDOX %5 KREM, 30 G, EXPAN® 50 MG
  4. Target

    Stromal cell-derived factor 1

    go.drugbank.com/bio_entities/BE0001150
    TargetHumans

    Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity)

    Synonyms: Pre-B cell growth-stimulating factor
  5. Drug

    Migalastat

    go.drugbank.com/drugs/DB05018
    ApprovedInvestigational

    migalastat therapy, Amicus Therapeutics' brand name Galafold was approved using the Accelerated Approval pathway, under which the FDA may approve drugs for serious conditions where there is an unmet medical … Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A).

    Synonyms: 1-Deoxygalactostatin, 1-DeoxygalactonojirimycinCategories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones, Heterocyclic Compounds, 1-Ring
  6. Drug

    Ivermectin

    go.drugbank.com/drugs/DB00602
    ApprovedInvestigationalVet approved

    While studies are still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and the clinical utility of this data remains unclear. … [L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de

    Mixtures: Ivermectin 1% / Metronidazole 1% / Niacinamide 4%, Ivermectin 1% / Metronidazole 1%Categories: P-glycoprotein inducers, P-glycoprotein inhibitors
  7. Drug

    Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB10584
    ApprovedInvestigational

    Mixtures: -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE, 3 ANTIGEN
  8. Drug

    Levomenthol

    go.drugbank.com/drugs/DB00825
    ApprovedInvestigational

    Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.

    Synonyms: (1R-(1-α,2-β,5-α))-5-methyl-2-(1-methylethyl)cyclohexanol, CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1R-(1.ALPHA.,2.BETA.,5.ALPHA.))-Mixtures: TOKUSEN MEDICAL PLASTER, Pishuho Medical Plaster
  9. Drug

    Nabilone

    go.drugbank.com/drugs/DB00486
    ApprovedInvestigational

    From a pharmacological perspective, Cannabis' diverse receptor profile explains its potential application for such a wide variety of medical conditions. … Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: Canemes 1 mg Kapseln
  10. Drug

    Docusate

    go.drugbank.com/drugs/DB11089
    ApprovedInvestigational

    Still docusate is available in over-the-counter products as a common laxative. … Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201].

    Mixtures: Taron-prex Prenatal, Senna-SProducts: H E B Stool Softener laxative, Doc Q Lace