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Displaying results 481 - 490 of 2828 in total
  1. Drug

    Ethoxzolamide

    go.drugbank.com/drugs/DB00311
    ApprovedWithdrawn

    Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confe...

    Categories: Genito Urinary System and Sex Hormones
  2. Drug

    Maribavir

    go.drugbank.com/drugs/DB06234
    ApprovedInvestigational

    Maribavir is an inhibitor of the cytomegalovirus (CMV; HHV5) pUL97 kinase which is used to treat CMV infections in patients post-transplantation. Most standard CMV therapies, such as ganciclovir or foscarnet, target CMV DNA polymerase - ...

  3. Drug

    Imipramine

    go.drugbank.com/drugs/DB00458
    ApprovedInvestigational

    Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In...

    Categories: Membrane Transport Modulators
  4. Indication

    Pasteurella infections

    go.drugbank.com/conditions/DBCOND0024235
    Drugs: Benzylpenicillin
    Synonyms: Transport fever
  5. Drug

    Ciclopirox

    go.drugbank.com/drugs/DB01188
    ApprovedInvestigational

    Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective ...

    Categories: Genito Urinary System and Sex Hormones
  6. Target

    Proteasome activator complex subunit 1

    go.drugbank.com/bio_entities/BE0008976
    TargetHumans

    The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome

    Polypeptides: Proteasome activator complex subunit 1Synonyms: 11S regulator complex subunit alpha
  7. Target

    MHC class II protein complex

    go.drugbank.com/bio_entities/BE0011001
    TargetHumans

  8. Drug

    Methazolamide

    go.drugbank.com/drugs/DB00703
    Approved

    A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

    Categories: Genito Urinary System and Sex Hormones
  9. Drug

    Amifampridine

    go.drugbank.com/drugs/DB11640
    Approved

    In phase III clinical trials of adult patients with LEMS, treatment of amifampridine significantly improved symptoms of LEMS compared to placebo with good tolerance [A33864].

    Categories: Membrane Transport Modulators
  10. Indication

    Tuberous Sclerosis Complex with Subependymal Giant Cell Astrocytoma

    go.drugbank.com/conditions/DBCOND0025535
    Drugs: Everolimus
    Synonyms: Tuberous Sclerosis Complex with Subependymal Giant Cell Astrocytoma