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Buprenorphine

Clinically, this results in a slow onset of action and a clinical phenomenon known as the "ceiling effect" where once a certain dose is reached, buprenorphine's effects plateau. … Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.

Niclosamide

Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases.

Moxonidine

Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension.

Elvucitabine

Genistein

It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. … Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties.

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting.

Oxamniquine

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female wor...

GC-376 free acid

The compound is known as a direct acting antiviral (DAA) for coronaviruses, and was initially developed using structure-guided design to combat MERS-Cov infections[A219036,A219056]. … A prodrug of [GC-373], GC-376 has recently been used to test inhibition of SARS-Cov-2 M^pro _in vitro_, and results show potent inhibition of this target[A219036].

Molsidomine

Interestingly, it is being studied as being a preventive measure in cerebral infarction [A31932].

Ibopamine