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Tropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnTropisetron is an indole derivative with antiemetic activity. … As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: NAVOBAN 5 MG 1 AMPUL, Navoban 5 mg - KapselnLinerixibat
go.drugbank.com/drugs/DB11729ApprovedInvestigationalLinerixibat is a first-in-class and small-molecule inhibitor of the ileal bile acid transporter (IBAT). … [L56127] PBC is a rare, chronic autoimmune liver disease characterized by the destruction of small bile ducts, leading to cholestasis and the systemic accumulation of bile acids, which are hypothesized
Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: 3-((((3R,5R)-3-BUTYL-3-ETHYL-7-METHOXY-1,1-DIOXO-5-PHENYL-2,3,4,5-TETRAHYDRO- 1H-1.LAMBDA.6,4-BENZOTHIAZEPIN-8-YL)METHYL)AMINO)PENTANEDIOIC ACID, PENTANEDIOIC ACID, 3-((((3R,5R)-3-BUTYL-3-ETHYL-2,3,4,5-TETRAHYDRO-7-METHOXY-1,1-DIOXIDO-5-PHENYL-1,4-BENZOTHIAZEPIN-8-YL)METHYL)AMINO)-Lasmiditan
go.drugbank.com/drugs/DB11732ApprovedInvestigational[L9338,L9356] It was also approved by the European Commission on August 17, 2022.[L43997] Traditionally, the triptan class of anti-migraine medications (e.g. … [A187316,A187322] Lasmiditan, in contrast, is a highly selective agonist of 5-HT<sub>1F</sub> receptors, carrying virtually no affinity for other receptors which appear to be largely responsible for
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsProducts: 1 RayvowRifamycin
go.drugbank.com/drugs/DB11753ApprovedInvestigationalWithdrawn[A39990] Rifamycin has had several direct derivative products such as rifamycin SV, rifaximin, rifampin and rifamycin CV. … Product which allowed it to have a status a priority review.
Mixtures: RIFETEM 250 MG / 3 ML AMPUL, 1 ADET, RİF 250 MG/3 ML IM ENJEKSİYONLUK ÇÖZELTİ (1 AMPUL)Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsDanoprevir
go.drugbank.com/drugs/DB11779InvestigationalDanoprevir has been used in trials studying the treatment of Hepatitis C, Chronic.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP3A InhibitorsFostemsavir
go.drugbank.com/drugs/DB11796ApprovedInvestigational[L14867] It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir … Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor.
Categories: Human Immunodeficiency Virus Type 1 (HIV-1) gp120-directed Attachment Inhibitors, Cytochrome P-450 SubstratesFaldaprevir
go.drugbank.com/drugs/DB11808InvestigationalFaldaprevir has been investigated for the treatment of Chronic Hepatitis C.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingTalaporfin
go.drugbank.com/drugs/DB11812InvestigationalTalaporfin has been investigated for the treatment of Port-Wine Stain and Benign Prostatic Hyperplasia.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsTilarginine
go.drugbank.com/drugs/DB11815ApprovedInvestigationalWithdrawnTilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.
Synonyms: N(G)-Monomethyl-L-arginine, N(G)-MethylarginineMocetinostat
go.drugbank.com/drugs/DB11830InvestigationalMocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others.
Categories: Heterocyclic Compounds, 1-Ring