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Displaying results 41 - 50 of 597 in total
  1. Pathway

    Furosemide Action Pathway

    smpdb.ca/view/SMP0000115
    Drug action

    Furosemide can bind and inhibit sodium-potassium-chloride cotransporter (NKCC2/SLC22A1) to prevent the water reabsorption in nephron. … Inhibition of sodium-potassium-chloride cotransporter can prevent transportation of sodium from lumen to basolateral interstitium, which lead to more hypertonic in lumen and less hypertonic in basolateral

    Drugs: Cysteine · Furosemide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  2. Pathway

    Trichlormethiazide Action Pathway

    smpdb.ca/view/SMP0000121
    Drug action

    Trichloromethiazide acts by inhibiting chloride and potentially sodium reabsorption in the ascending loop of Henle, specifically at solute carrier family 12 member 3. … Trichlormethiazide also acts to inhibit sodium uptake and increase potassium excretion which also serves to increase fluid loss.

    Drugs: Cysteine · Trichlormethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  3. Pathway

    Chlorothiazide Action Pathway

    smpdb.ca/view/SMP0000078
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Chlorothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  4. Pathway

    Bumetanide Action Pathway

    smpdb.ca/view/SMP0000088
    Drug action

    In the thick ascending limb of the loop of Henle, the sodium-potassium-chloride cotransporter (NKCC2) is competitively inhibited at the chloride binding site blocking sodium transport from the lumen to … In the nephron, the think ascending limb reabsorbs 25% of sodium and is a good target for diuretics.

    Drugs: Cysteine · Bumetanide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  5. Pathway

    Cyclothiazide Action Pathway

    smpdb.ca/view/SMP0000103
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Cyclothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  6. Pathway

    Metolazone Action Pathway (old)

    smpdb.ca/view/SMP0000105
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Metolazone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  7. Pathway

    Bendroflumethiazide Action Pathway (New)

    smpdb.ca/view/SMP0123062
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Bendroflumethiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Pathway

    Methyclothiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123143
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Methyclothiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  9. Pathway

    Trichlormethiazide Action Pathway (New)

    smpdb.ca/view/SMP0123150
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Trichlormethiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  10. Pathway

    Metolazone Action Pathway

    smpdb.ca/view/SMP0123151
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Metolazone · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1