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KB3305
go.drugbank.com/drugs/DB06349ExperimentalKB3305 is an investigational liver selective antagonist for the glucocorticoid receptor, developed by Karo Bio for the treatment of Type 2 Diabetes.
Categories: EstranesSynonyms: (4R)-4-((3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-DIHYDROXY-3-(2-(4-((8S,11R,13S,14S,17S)-17-HYDROXY-13-METHYL-3-OXO-17-PROP-1-YNYL-1,2,6,7,8,11,12,14,15,16-DECAHYDROCYCLOPENTA(A)PHENANTHREN-11-YL)-N-METHYL-ANILINO, .)-17-HYDROXY-3-OXO-17-(1-PROPYN-1-YL)ESTRA-4,9-DIEN-11-YL)PHENYL)METHYLAMINO)ETHOXY)CHOLAN-24-OIC ACIDNitric oxide synthase
go.drugbank.com/bio_entities/BE0010197TargetEnzymeProduces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. … Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832).
Synonyms: Inducible NO synthaseVayarin
go.drugbank.com/drugs/DB09328ApprovedVayarin is currently available only by prescription in the USA [L1502]. This drug has also been used for management of hypertriglyceridemia [L1503]. … Vayarin is an orally administered prescription medical food for the clinical dietary management of complex lipid imbalances thought to be associated with ADHD.
Oxygen
go.drugbank.com/drugs/DB09140ApprovedInvestigationalVet approvedOxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. … an attempt to oxygenate the lungs.
Mixtures: Lung Diffusion Test Mix No Ne Co, Co-NE-O2-N2 MixtureProducts: N/AAmyl Nitrite
go.drugbank.com/drugs/DB01612ApprovedAmyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. … As an inhalant, it also has psychoactive effect which has led to illegal drug use.
Synonyms: n-Amyl nitrite, n-pentyl nitriteDonepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigationalDonepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia. … [L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia.
International brands: Nomi-NoxProducts: Nb-donepezilLamotrigine
go.drugbank.com/drugs/DB00555ApprovedInvestigational[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring.
Products: Nu-lamotrigineEnsulizole
go.drugbank.com/drugs/DB11115ApprovedIt was demonstrated by studies that ensulizole treatment provided protection against cyclobutane pyrimidine dimers and photosensitized the formation of oxidized guanine bases after UV-A or UV-B exposure … Due to its water solubility, ensulizole is commonly used in products formulated to feel light and less oily [A32259].
Mixtures: Too Cool For School DINOPLATZ La Ola Noche No.23, Too Cool For School DINOPLATZ La Ola Viento No.21Acemetacin
go.drugbank.com/drugs/DB13783ApprovedInvestigationalMerck and Company in Germany as an attempt to provide a safer drug but other than the amelioration on the gastrointestinal effects, the metabolism of acetamicin led to the formation of indomethacin and … [A31352] In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.[T50] It was developed by E.
Categories: Analgesics, Non-Narcotic, Non COX-2 selective NSAIDSTryptophan
go.drugbank.com/drugs/DB00150ApprovedInvestigationalNutraceuticalWithdrawnIt can be a precursor to niacin, albeit inefficiently, in mammals.
Mixtures: Vamin N, AMINOSTERIL N-HEPA 8%Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome