Identification

Name
Oxygen
Accession Number
DB09140
Description

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Thumb
Weight
Average: 31.9988
Monoisotopic: 31.989829244
Chemical Formula
O2
Synonyms
  • Dioxygen
  • Molecular oxygen
  • Oxigeno gaseoso
  • Oxygen USP
  • Pure oxygen
External IDs
  • E-948
  • INS NO.948
  • INS-948

Pharmacology

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia 6 to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics

Oxygen therapy improves effective cellular oxygenation, even at a low rate of tissue perfusion. Oxygen molecules adjust hypoxic ventilatory drive by acting on chemoreceptors on carotid bodies that sequentially relay sensory information to the higher processing centers in brainstem. It also attenuates hypoxia-induced mitochondrial depolarization that generates reactive oxygen species and/or apoptosis. Studies investigating on hyperbaric oxygen therapy has shown that oxygen supplementation can induce neural stem cell proliferation in neonatal rats thus promoting neurological regeneration after injuries 3. CD34+, CD45-dim leukocytes are also potential targets for hyperbaric oxygen therapy benefit as their mobilization was increased in vitro which could facilitate the acceleration of recovery at peripheral sites 1.

Mechanism of action

Oxygen therapy increases the arterial pressure of oxygen and is effective in improving gas exchange and oxygen delivery to tissues, provided that there are functional alveolar units. Oxygen plays a critical role as an electron acceptor during oxidative phosphorylation in the electron transport chain through activation of cytochrome c oxidase (terminal enzyme of the electron transport chain). This process achieves successful aerobic respiration in organisms to generate ATP molecules as an energy source in many tissues. Oxygen supplementation acts to restore normal cellular activity at the mitochondrial level and reduce metabolic acidosis. There is also evidence that oxygen may interact with O2-sensitive voltage-gated potassium channels in glomus cells and cause hyperpolarization of mitochondrial membrane 4.

TargetActionsOrganism
UCytochrome c oxidase subunit 1
agonist
activator
Humans
UNADPH oxidase 1
agonist
activator
Humans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding

Oxygen binds to oxygen-carrying protein in red blood cells called hemoglobin with high affinity. The amount of oxygen molecules bound to the fixed amount of circulating hemoglobin in the blood determines the overall oxygen saturation level and this oxygen-delivering capacity is regulated by Bohr effect.

Metabolism
Not Available
Route of elimination

Exhalation

Half-life

Approximately 122.24 seconds

Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity

May cause burns or frostbites in case of eye or skin contact with rapidly expanding gas. Oxygen therapy can induce hypercapnic respiratory failure in patients with respiratory diseases and musculoskeletal diseases in upper airways. Sudden cessation of oxygen supplementation in these patients can further lead to rebound hypoxaemia. In patients with mild or moderate strokes, hyperoxaemia may cause absorption atelectasis or myocardial infarction. Oxygen content should be monitored following the administration to verify therapeutic benefit.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
40% Oxygen/Nitrogen MixGas400 mL/1LRespiratory (inhalation)NexAir LLC2020-04-09Not applicableUS flag
AirGas20.9 L/100LRespiratory (inhalation)Indianapolis Welding Supply, Inc1972-01-012013-04-12US flag
AirGas195 mL/1000mLRespiratory (inhalation)Industrial Gas Distributors Inc1987-04-012015-12-29US flag
AirGas21 L/1LRespiratory (inhalation)Lampton Welding Supply Company, Inc2018-04-18Not applicableUS flag
AirGas210 mL/1LRespiratory (inhalation)Airgas Mid South, Inc.1997-11-062010-03-02US flag
AirGas210 mL/1LRespiratory (inhalation)Airgas Usa, Llc1997-11-062014-03-31US flag
AirGas210 mL/1LRespiratory (inhalation)Roberts Oxygen Company, Inc.1967-01-01Not applicableUS flag
AirGas210 mL/1LRespiratory (inhalation)Inland Welding Supply dba A-L Compressed Gases2005-07-01Not applicableUS flag
AirGas235 mL/1LRespiratory (inhalation)- INDUSTRIAL WELDING SUPPLY CO. OF HARVEY, INC.2018-12-17Not applicableUS flag
AirGas210 mL/1LRespiratory (inhalation)Industrial Source2016-08-01Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
OxygenGas992 mL/1LRespiratory (inhalation)Arkansas Welding & Industrial Supply2001-10-20Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Air USPOxygen (19.5 %) + Nitrogen (80.5 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada flag
Alnox GasOxygen (50 %) + Nitrous oxide (50 %)GasRespiratory (inhalation)Air Liquide Canada Inc.1995-12-31Not applicableCanada flag
CarbogenOxygen (50 %) + Carbon dioxide (50 %)GasRespiratory (inhalation)Messer Canada Inc.1995-12-31Not applicableCanada flag
Carbon Dioxide 1% W OxygenOxygen (93 %) + Carbon dioxide (7 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada flag
Carbon Dioxide 12.1% W OxygenOxygen (77 %) + Carbon dioxide (23 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada flag
Carbon Dioxide 23.1% W OxygenOxygen (50 %) + Carbon dioxide (50 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada flag
Carbon Dioxide 7.1% W OxygenOxygen (88 %) + Carbon dioxide (12 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada flag
Carbon Dioxide In Oxygen MixtureOxygen (90 %) + Carbon dioxide (10 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1983-12-311997-12-24Canada flag
Carbon Dioxide MixtureOxygen (23 %) + Carbon dioxide (12 %) + Nitrogen (65 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada flag
Carbon Dioxide USP, Oxygen USP Medical G.M.Oxygen (93 %) + Carbon dioxide (7 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AirOxygen (210 mL/1L)GasRespiratory (inhalation)Airgas Mid South, Inc.1997-11-062010-03-02US flag
AirOxygen (210 mL/1L)GasRespiratory (inhalation)Airgas Usa, Llc1997-11-062014-03-31US flag
AirOxygen (20.9 L/100L)GasRespiratory (inhalation)Indianapolis Welding Supply, Inc1972-01-012013-04-12US flag
AirOxygen (23 L/100L) + Nitrogen (77 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-01Not applicableUS flag
AirOxygen (99 L/100L) + Nitrogen (99 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-012010-06-15US flag
AirOxygen (195 mL/1000mL)GasRespiratory (inhalation)Industrial Gas Distributors Inc1987-04-012015-12-29US flag
AirOxygen (210 mL/1L)GasRespiratory (inhalation)Praxair, Puerto Rico Inc.2005-10-01Not applicableUS flag
Air CompressedOxygen (20 L/100L)GasRespiratory (inhalation)Specialty Gases Of America1995-01-012015-06-10US flag
Air Compressed Medical AirOxygen (21 L/100L)GasRespiratory (inhalation)Vagabond Welding Supply2013-04-01Not applicableUS flag
CarbogenOxygen (95 mL/1L) + Carbon dioxide (5 mL/1L)GasRespiratory (inhalation)WestAir Gases and Equipment, Inc.2000-01-01Not applicableUS flag

Categories

ATC Codes
V03AN01 — Oxygen
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal oxides
Direct Parent
Other non-metal oxides
Alternative Parents
Inorganic oxides
Substituents
Inorganic oxide / Other non-metal oxide
Molecular Framework
Not Available
External Descriptors
diatomic oxygen, elemental molecule (CHEBI:15379) / a non-metabolic compound (OXYGEN-MOLECULE)

Chemical Identifiers

UNII
S88TT14065
CAS number
7782-44-7
InChI Key
MYMOFIZGZYHOMD-UHFFFAOYSA-N
InChI
InChI=1S/O2/c1-2
IUPAC Name
oxidanone
SMILES
O=O

References

General References
  1. Heyboer M 3rd, Milovanova TN, Wojcik S, Grant W, Chin M, Hardy KR, Lambert DS, Logue C, Thom SR: CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res. 2014 May;12(3):638-45. doi: 10.1016/j.scr.2014.02.005. Epub 2014 Feb 28. [PubMed:24642336]
  2. Prabhakar NR: Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol (1985). 2000 Jun;88(6):2287-95. [PubMed:10846047]
  3. Feng Z, Liu J, Ju R: Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage. Neural Regen Res. 2013 May 5;8(13):1220-7. doi: 10.3969/j.issn.1673-5374.2013.13.007. [PubMed:25206416]
  4. Lopez-Barneo J, Gonzalez-Rodriguez P, Gao L, Fernandez-Aguera MC, Pardal R, Ortega-Saenz P: Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia. Am J Physiol Cell Physiol. 2016 Apr 15;310(8):C629-42. doi: 10.1152/ajpcell.00265.2015. Epub 2016 Jan 13. [PubMed:26764048]
  5. Liu W, Khatibi N, Sridharan A, Zhang JH: Application of medical gases in the field of neurobiology. Med Gas Res. 2011 Jun 27;1(1):13. doi: 10.1186/2045-9912-1-13. [PubMed:22146102]
  6. British Thoracic Society: Guideline for emergency oxygen use in adult patients [Link]
  7. Airgas SDS [Link]
  8. Linde SDS [Link]
Human Metabolome Database
HMDB0001377
KEGG Drug
D00003
KEGG Compound
C00007
PubChem Compound
977
PubChem Substance
310265054
ChemSpider
952
RxNav
7806
ChEBI
27140
ChEMBL
CHEMBL1234886
PharmGKB
PA450744
PDBe Ligand
OXY
Drugs.com
Drugs.com Drug Page
Wikipedia
Oxygen
AHFS Codes
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
PDB Entries
1a4f / 1a6m / 1ash / 1b86 / 1dcc / 1dp6 / 1dz8 / 1e5d / 1f65 / 1faw
show 396 more
MSDS
Download (177 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentAcute Lung Injury (ALI) / Cardiopulmonary Bypass / Hyperoxia / Oxygen Toxicity / Surgery, Cardiac1
4Active Not RecruitingTreatmentInterstitial Lung Diseases (ILD) / Precapillary Pulmonary Hypertension2
4CompletedBasic ScienceHyperoxia / Hypoxia, Brain / Neurobehavioral Manifestations1
4CompletedPreventionLaparotomy2
4CompletedPreventionPostoperative Cardiac Complication1
4CompletedTreatmentAcute Coronary Syndromes (ACS)1
4CompletedTreatmentAnalgesia / Bowel Cancer Screening / Colonoscopy / Entonox1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)4
4CompletedTreatmentInfants / Persistent foetal circulation disorders / Respiratory Failure1
4CompletedTreatmentSepsis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GasRespiratory (inhalation)195 mL/1000mL
GasRespiratory (inhalation)20.9 L/100L
GasRespiratory (inhalation)21 L/1L
GasRespiratory (inhalation)235 mL/1L
GasRespiratory (inhalation)20 %
GasRespiratory (inhalation)21 %
GasRespiratory (inhalation)950 mL/1L
GasRespiratory (inhalation)50 mL/1L
GasRespiratory (inhalation)80 L/100L
GasRespiratory (inhalation)90 L/100L
GasRespiratory (inhalation)96 L/100L
GasRespiratory (inhalation)40 L/100L
GasRespiratory (inhalation)95 L/100L
GasRespiratory (inhalation)20 L/100L
GasRespiratory (inhalation)25 L/100L
GasRespiratory (inhalation)30 L/100L
GasRespiratory (inhalation)
Gas
GasRespiratory (inhalation)79 %
GasRespiratory (inhalation)60 %
GasRespiratory (inhalation)70 %
GasRespiratory (inhalation)21 L/100L
GasRespiratory (inhalation)23 L/100L
GasRespiratory (inhalation)0.47 L/0.47L
GasRespiratory (inhalation)11 L/11L
GasRespiratory (inhalation)12 L/12L
GasRespiratory (inhalation)4 L/4L
GasRespiratory (inhalation)20 L/20L
GasRespiratory (inhalation)0.66 L/0.66L
GasRespiratory (inhalation)0.95 L/0.95L
GasRespiratory (inhalation)30 L/30L
GasRespiratory (inhalation)1500 L/1500L
GasRespiratory (inhalation)5000 L/5000L
GasRespiratory (inhalation)18 L/18L
GasRespiratory (inhalation)0.5 L/0.5L
GasRespiratory (inhalation)1 L/L
GasRespiratory (inhalation)10 L/10L
GasRespiratory (inhalation)100 %
GasRespiratory (inhalation)14 L/14L
GasRespiratory (inhalation)2 L/2L
GasRespiratory (inhalation)27 L/27L
GasRespiratory (inhalation)3 L/3L
GasRespiratory (inhalation)40 L/40L
GasRespiratory (inhalation)5 L/5L
GasRespiratory (inhalation)50 L/50L
GasRespiratory (inhalation)7 L/7L
GasRespiratory (inhalation)23.6 L/23.6L
GasRespiratory (inhalation)33 L/33L
GasRespiratory (inhalation)8.75 L/8.75L
GasRespiratory (inhalation)10 L
GasRespiratory (inhalation)1000 L
GasRespiratory (inhalation)10000 L
GasRespiratory (inhalation)12000 L
GasRespiratory (inhalation)1500 L
GasRespiratory (inhalation)15000 L
GasRespiratory (inhalation)160 L
GasRespiratory (inhalation)180 L
GasRespiratory (inhalation)2000 L
GasRespiratory (inhalation)20000 L
GasRespiratory (inhalation)21 L
GasRespiratory (inhalation)230 L
GasRespiratory (inhalation)2500 L
GasRespiratory (inhalation)3000 L
GasRespiratory (inhalation)30000 L
GasRespiratory (inhalation)31 L
GasRespiratory (inhalation)32 L
GasRespiratory (inhalation)36 L
GasRespiratory (inhalation)4000 L
GasRespiratory (inhalation)40000 L
GasRespiratory (inhalation)41 L
GasRespiratory (inhalation)46 L
GasRespiratory (inhalation)5000 L
GasRespiratory (inhalation)6000 L
GasRespiratory (inhalation)60 L/60L
GasRespiratory (inhalation)0.74 L/0.74L
GasRespiratory (inhalation)1.34 L/1.34L
GasRespiratory (inhalation)15 L/15L
GasRespiratory (inhalation)17 L/17L
GasRespiratory (inhalation)24 L/24L
GasRespiratory (inhalation)25.5 L/25.5L
GasRespiratory (inhalation)28 L/28L
GasRespiratory (inhalation)50 %
GasRespiratory (inhalation)90 %
GasRespiratory (inhalation)93 % v/v
GasRespiratory (inhalation)93 %
GasRespiratory (inhalation)99 % v/v
GasRespiratory (inhalation)99 v/v
GasRespiratory (inhalation)99.5 %
GasRespiratory (inhalation)6.5 m3
GasRespiratory (inhalation)94.9722 % v/v
GasRespiratory (inhalation)100 % v/v
GasRespiratory (inhalation)99 %
GasRespiratory (inhalation)7.5 L/7.5L
Gas
GasCutaneous; Respiratory (inhalation)992 mL/1L
GasNasal1 L/1L
GasNasal210 mL/1L
GasNasal99 L/100L
GasNasal; Respiratory (inhalation)1 L/1L
GasNasal; Respiratory (inhalation)995 mL/1L
GasRespiratory (inhalation).99 L/1L
GasRespiratory (inhalation).995 L/1L
GasRespiratory (inhalation)100 L/99L
GasRespiratory (inhalation)1000 mL/1L
GasRespiratory (inhalation)210 mL/1L
GasRespiratory (inhalation)900 mL/1L
GasRespiratory (inhalation)93 mL/1L
GasRespiratory (inhalation)930 mL/1L
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)99 L/1L
GasRespiratory (inhalation)99 L/99L
GasRespiratory (inhalation)99 mL/1L
GasRespiratory (inhalation)99 mL/100mL
GasRespiratory (inhalation)99.0 %
GasRespiratory (inhalation)99.1 L/1L
GasRespiratory (inhalation)99.4 L/100L
GasRespiratory (inhalation)99.5 L/1L
GasRespiratory (inhalation)99.5 L/100L
GasRespiratory (inhalation)99.6 L/100L
GasRespiratory (inhalation)99.6 %
GasRespiratory (inhalation)99.6 L/1L
GasRespiratory (inhalation)99.8 L/1L
GasRespiratory (inhalation)99.8 L/100L
GasRespiratory (inhalation)99.9 L/100L
GasRespiratory (inhalation)99.9 mL/1L
GasRespiratory (inhalation)99.9 L/1L
GasRespiratory (inhalation)990 mL/1L
GasRespiratory (inhalation)990 L/1L
GasRespiratory (inhalation)990 1/1L
GasRespiratory (inhalation)991 mL/1L
GasRespiratory (inhalation)992 mL/1L
GasRespiratory (inhalation)992 L/1000L
GasRespiratory (inhalation)992 mL/1000mL
GasRespiratory (inhalation)992 1/1L
GasRespiratory (inhalation)995 mL/1L
GasRespiratory (inhalation)995 mL/100L
GasRespiratory (inhalation)995 L/1L
GasRespiratory (inhalation)996 mL/1L
GasRespiratory (inhalation)997 mL/1L
GasRespiratory (inhalation)998 mL/1L
GasRespiratory (inhalation)999 L/1000L
GasRespiratory (inhalation)999 mL/1L
LiquidRespiratory (inhalation)1.13835106 kg/1L
LiquidRespiratory (inhalation)1000 g/1L
LiquidRespiratory (inhalation)210 mg/1kg
LiquidRespiratory (inhalation)99 1/100L
LiquidRespiratory (inhalation)99 L/100L
LiquidRespiratory (inhalation)992 L/1000L
LiquidRespiratory (inhalation)995 mL/1L
LiquidRespiratory (inhalation)999 L/1000L
GasRespiratory (inhalation)992 mL/100mL
GasRespiratory (inhalation)0.995 mL/1L
GasRespiratory (inhalation)200 mL/1L
GasRespiratory (inhalation)0.99 kg/1kg
GasRespiratory (inhalation)11321 L/11321L
GasRespiratory (inhalation)196 L/196L
GasRespiratory (inhalation)240 L/240L
GasRespiratory (inhalation)396 L/396L
GasRespiratory (inhalation)659 L/659L
GasRespiratory (inhalation)1567 L/1567L
GasRespiratory (inhalation)6931 L/6931L
GasRespiratory (inhalation)3453 L/3453L
GasRespiratory (inhalation)8688 L/8688L
GasNasal; Oral
GasRespiratory (inhalation)250 mL/1L
GasRespiratory (inhalation)300 mL/1L
GasRespiratory (inhalation)330 mL/1L
GasRespiratory (inhalation)400 mL/1L
GasRespiratory (inhalation)500 mL/1L
GasRespiratory (inhalation)600 mL/1L
GasRespiratory (inhalation)800 mL/1L
Gas; liquidRespiratory (inhalation)
GasRespiratory (inhalation)99.2 %
LiquidRespiratory (inhalation)1 L/1L
GasRespiratory (inhalation)1 L/1L
GasRespiratory (inhalation)
Prices
Not Available
Patents
Not Available

Properties

State
Gas
Experimental Properties
PropertyValueSource
melting point (°C)-218.4Airgas SDS
boiling point (°C)-183Airgas SDS
water solubility39mg/LLinde SDS
logP0.65SDS
Predicted Properties
PropertyValueSource
logP-0.28ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.89 m3·mol-1ChemAxon
Polarizability1.53 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-5e864878b295db174473
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-5e864878b295db174473
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-5e864878b295db174473

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
Activator
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic su...
Gene Name
MT-CO1
Uniprot ID
P00395
Uniprot Name
Cytochrome c oxidase subunit 1
Molecular Weight
57040.91 Da
References
  1. Wilson MT, Antonini G, Malatesta F, Sarti P, Brunori M: Probing the oxygen binding site of cytochrome c oxidase by cyanide. J Biol Chem. 1994 Sep 30;269(39):24114-9. [PubMed:7929065]
  2. Thomson AJ, Greenwood C, Gadsby PM, Peterson J, Eglinton DG, Hill BC, Nicholls P: The structure of the cytochrome a3-CuB site of mammalian cytochrome c oxidase as probed by MCD and EPR spectroscopy. J Inorg Biochem. 1985 Mar-Apr;23(3-4):187-97. [PubMed:2991457]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
Activator
General Function
Voltage-gated proton channel activity
Specific Function
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is ...
Gene Name
NOX1
Uniprot ID
Q9Y5S8
Uniprot Name
NADPH oxidase 1
Molecular Weight
64870.455 Da
References
  1. Smith RG: An appraisal of potential drug interactions regarding hyperbaric oxygen therapy and frequently prescribed medications. Wounds. 2011 Jun;23(6):147-59. [PubMed:25881361]
  2. Prabhakar NR: Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol (1985). 2000 Jun;88(6):2287-95. [PubMed:10846047]

Carriers

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
Curator comments
Binding increases the affinity of other binding sites for oxygen.
General Function
Oxygen transporter activity
Specific Function
Involved in oxygen transport from the lung to the various peripheral tissues.LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.Spinorphin: functions as an...
Gene Name
HBB
Uniprot ID
P68871
Uniprot Name
Hemoglobin subunit beta
Molecular Weight
15998.34 Da
References
  1. Hamilton HB, Iuchi I, Miyaji T, Shibata S: Hemoglobin Hiroshima (beta-143 histidine--aspartic acid): a newly identified fast moving beta chain variant associated with increased oxygen affinity and compensatory erythremia. J Clin Invest. 1969 Mar;48(3):525-35. [PubMed:5773089]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
General Function
Oxygen transporter activity
Specific Function
Involved in oxygen transport from the lung to the various peripheral tissues.
Gene Name
HBA1
Uniprot ID
P69905
Uniprot Name
Hemoglobin subunit alpha
Molecular Weight
15257.405 Da
References
  1. Miyashita H, Hashimoto K, Mohri H, Ohokubo T, Harano T, Harano K, Imai K: Hb Kanagawa [alpha 40(C5)Lys----Met]: a new alpha chain variant with an increased oxygen affinity. Hemoglobin. 1992;16(1-2):1-10. [PubMed:1634355]

Drug created on September 30, 2015 10:55 / Updated on October 19, 2020 07:47

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As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates