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Displaying results 491 - 500 of 10000 in total
  1. Drug

    Ergoloid mesylate

    go.drugbank.com/drugs/DB01049
    Approved

    [A32912] All these components are produced by the fungus _Claviceps purpurea_ and are all derivatives of the tetracyclic compound 6-methylergonovine. … [A32914] The mixture of ergoloid mesylate was first developed by Novartis and FDA approved on November 5, 1953, but this specific formulation is now discontinued.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Hydergine LC, อินเดอร์จิน 1 มก.
  2. Drug

    Mepivacaine

    go.drugbank.com/drugs/DB00961
    ApprovedInvestigationalVet approved

    A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. … Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

    Mixtures: MEPISEAL-E, Scandonest LCategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Leuprolide

    go.drugbank.com/drugs/DB00007
    ApprovedInvestigational

    Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). … [A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename Lupron™ by Abbvie Endocrine Inc.

    International brands: Prostap 3Products: Lupron Depot Ped, Lupron Depot-PED
  4. Drug

    Pyrithione

    go.drugbank.com/drugs/DB06815
    ApprovedInvestigational

    Pyrithione zinc, or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. … Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such as _Malassezia globosa_ and _M. restricta_ [A32162].

    Synonyms: 2-pyridinethiol 1-oxide, Pyridinethiol N-oxideMixtures: Z-plus Shampoo, Neutrogena T/Gel Therapeutic
  5. Drug

    Davamotecan pegadexamer

    go.drugbank.com/drugs/DB05899
    Investigational

    EP0057 is a conjugate of Insert's proprietary drug delivery molecule, Cyclosert, and the potent anti-cancer compound [camptothecin].

    Categories: Compounds used in a research, industrial, or household settingSynonyms: Poly CD PEG camptothecin, poly-CD-PEG-camptothecin
  6. Drug

    Tilactase

    go.drugbank.com/drugs/DB13761
    ApprovedInvestigational

    Tilactase is a beta-D-galactosidase obtained from _Aspergillus oryzae_. It is produced as a chewable tablet that has to be taken before the consumption of a lactose-containing meal. … [A27172] The beta-D-galactosidase us a large monomeric multi-domain enzyme of 985 residues that presents a catalytic (alpha/beta)8-barrel domain.

    Synonyms: beta-D-GalactosidaseProducts: Lactase Enzyme Tablets 3300 Lac Units, LACDIGEST 2250 U CIGNEME TABLETI, 100 TABLET
  7. Drug

    St. John's Wort

    go.drugbank.com/drugs/DB01323
    ApprovedInvestigationalNutraceutical

    Mixtures: S. R. FormulaCategories: P-glycoprotein inducers, Cytochrome P-450 Substrates
  8. Drug

    Clonidine

    go.drugbank.com/drugs/DB00575
    ApprovedInvestigational

    [L7237,L54536,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237] … Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.

    Synonyms: 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine, 2-((2,6-Dichlorophenyl)imino)imidazolidineCategories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
  9. Drug

    Povidone-iodine

    go.drugbank.com/drugs/DB06812
    ApprovedInvestigational

    Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. … This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski.

    Synonyms: PVP-IMixtures: Dyural L Kit, Marbeta L Kit
  10. Drug

    Gadoteric acid

    go.drugbank.com/drugs/DB09132
    ApprovedInvestigational

    due to a decreased tendency of gadolinium dechelation. … Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA).

    Categories: Compounds used in a research, industrial, or household settingSynonyms: [2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl-κ4N1,N4,N7,N10)tetraacetato(3−)]gadolinium