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EP0057 is a conjugate of Insert's proprietary drug delivery molecule, Cyclosert, and the potent anti-cancer compound camptothecin.
- Mechanism
- Curator reviewed
IT-101 is a combination of its patented polymer technology, Cyclosert(TM), and the anti-cancer compound camptothecin. Insert's proprietary Cyclosert delivery system is based on small cyclic repeating molecules of glucose called cyclodextrins. Using modified cyclodextrins as building blocks, Insert has developed an entirely new proprietary class of materials called linear cyclodextrin-containing polymers. To the company's knowledge, Cyclosert is the first nanoparticulate drug delivery platform to be designed de novo and synthesized specifically to overcome limitations in existing delivery technologies used for the systemic delivery of therapeutics.
- Primary indication
- Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.Curator reviewed
- Also known as
- Poly CD PEG camptothecin · poly-CD-PEG-camptothecin
- Code names
- CRLX-101 · EP0057 · IT-101 · NLG-207
Resolves to
What you can answer from here — as of October 27, 2025
Which drugs share a target with Davamotecan pegadexamer, and which of those have an active Phase 3 trial?