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INM005
go.drugbank.com/drugs/DB16499InvestigationalINM005 was under investigation in clinical trials for the treatment of COVID-19. It was studied for pharmacokinetics, efficacy, and safety in a completed trial (NCT04494984). … Additionally, a retrospective cohort study investigated the effectiveness and safety of specific hyperimmune equine serum for severe hospitalized COVID-19 patients (NCT04954235)
Synonyms: INM-005 (PURIFIED FAB'2 FRACTION OF EQUINE HYPERIMMUNE SERUM GENERATED FROM ANTIGENIC STIMULATION WITH THE SARS-COV2 RBD PROTEIN)R1626
go.drugbank.com/drugs/DB05060ExperimentalR1626 is one of a new class of hepatitis C therapies called polymerase inhibitors. … It achieves significant reductions in viral load in chronic hepatitis C patients infected with the difficult to treat genotype 1 virus. R1626 is very effective in inhibiting viral replication
Pentosan polysulfate
go.drugbank.com/drugs/DB00686ApprovedInvestigationalPentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.
International brands: ComforaMebanazine
go.drugbank.com/drugs/DB09248ApprovedWithdrawnIt was used in the past as an antidepressant in the 1960s, but has since been discontinued because of its hepatotoxic potential. … Mebanazine, also known as _Actomol_, is a monoamine oxidase inhibitor (MAOI) belonging to the _hydrazine_ class of chemicals.
Lanolin alcohols
go.drugbank.com/drugs/DB14181ApprovedIt is administered as an ointment base with topical insulin and has shown to be antagonistic to wound healing. It is commonly used in allergenic testing. … Lanolin alcohols are a complex combination of organic alcohols obtained by the hydrolysis of lanolin.
Efzofitimod
go.drugbank.com/drugs/DB16453InvestigationalIt is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states. … Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody.
Oxabolone cipionate
go.drugbank.com/drugs/DB13185ExperimentalIt is considered as a performance enhancing drug thus is prohibited from use in sports. … Oxabolone cipionate is the C17β cypionate ester and a prodrug of [DB01500]. A synthetic anabolic-androgenic (AAS) steroid, it is a derivative of 19-nortestosterone (nandrolone).
Tezosentan
go.drugbank.com/drugs/DB06558InvestigationalTezosentan is an intravenous endothelin receptor A/B antagonist. … Tezosentan was initially developed for vasodilation in patients with acute heart failure but studies have shown that it does not assist in the treatment of dyspnea or prevent cardiovascular events.
Interferon Kappa
go.drugbank.com/drugs/DB15749Experimentala 27-amino acid signal peptide conserved in type I interferons. … This gene encoding for this interferon is expressed in human epidermal keratinocytes.
Synonyms: IFN‐κ