Pentosan polysulfate

DB00686ApprovedInvestigationalSmall moleculeGlycosaminoglycans

Pentosan polysulfate is a sulfated pentosyl polysaccharide used to treat bladder pain and discomfort due to interstitial cystitis.

Mechanism: Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Curator reviewed
Primary indication: For the relief of bladder pain or discomfort associated with interstitial cystitis.Curator reviewed · 1 structured indication
Formula / weight: C₁₀H₁₈O₂₁S₄ · 602.497 g/mol (avg)
First approval: Canada, 2002 · United States, 1996 · European Union, 2020
Also known as: (4-O-METHYL-.ALPHA.-D-GLUCURONO)-(1->2)-(1->4)-.BETA.-D-XYLOPYRANAN, HYDROGEN SULFATE · (4-O-METHYL-.ALPHA.-D-GLUCURONO)-(1->2)-(1->4)-.BETA.-D-XYLOPYRANAN, HYDROGEN SULPHATE · 4-O-METHYL-.ALPHA.-D-GLUCURONO-.BETA.-D-XYLAN, HYDROGEN SULFATE · 4-O-METHYL-.ALPHA.-D-GLUCURONO-.BETA.-D-XYLAN, HYDROGEN SULPHATE · PENTOSAN POLYSULPHATE
Code names: CB-8061
Brand names: Elmiron

Resolves to

Compound

UNIIF59P8B75R4CAS37300-21-3ChEMBLCHEMBL4073796ChEBI184555PubChem37720

Clinical / RWD

RxNorm155046ATCC05BA04ATCC05BA51ATCG04BX15PharmGKBPA164774806

Structure

InChIKeyFCCNSUIJIOOXEZ-SJYYZXOBSA-NSMILESO[C@@H]1CO[C@@H](O[C@@H]2CO[C@@H](O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O

Targets

P09038FGF2P05230FGF1P08620FGF4

What you can answer from here — as of September 13, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

718Drug interactionsStructured to mechanism, not free text

11Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

23Marketed productsAcross 7 countries and 13 labellers

3ATC codesIncluding every combination product, plus 19 drug categories

12+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pentosan polysulfate, and which of those have an active Phase 3 trial?

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