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Ibudilast
go.drugbank.com/drugs/DB05266InvestigationalIbudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume
NTx-265
go.drugbank.com/drugs/DB05649InvestigationalIt is also investigating use of the compound for neurodegenerative disorders, such as Huntington’s disease and Alzheimer’s disease.
Bafilomycin A1
go.drugbank.com/drugs/DB06733ExperimentalThis is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.
Octacosanol
go.drugbank.com/drugs/DB11220InvestigationalNutraceuticalIt has been studied as a potential therapeutic agent for the treatment of Parkinson's disease.
PDPSC18
go.drugbank.com/drugs/DB05167ExperimentalPDPSC18 is therapeutic DNA vaccine designed to fight chronic infections with the Hepatitis B virus, entering phase I clinical trials.
Oral Polio Vaccine
go.drugbank.com/drugs/DB15864InvestigationalThe oral polio vaccine (OPV) is a live attenuated vaccine containing a mixture of one or more strains of poliovirus serotypes. Strains of the virus are selected based on their reduced incidence of spreading to the central nervous system ...
Cobamamide
go.drugbank.com/drugs/DB11191ApprovedNutraceuticalIt is therefore important to treat vitamin B12 deficiency with a combination of MeCbl and AdCbl or hydroxocobalamin or cobalamin [L2054].
Osemozotan
go.drugbank.com/drugs/DB05339ExperimentalMN-305 is a novel, potent and highly selective serotonin 5-HT1A receptor agonist under development by MediciNova for the treatment of anxiety disorders beginning with Generalized Anxiety Disorder (GAD).
AME-527
go.drugbank.com/drugs/DB05879ExperimentalAME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity. AME-527 was generated by protein engineering and identified from a library of antibody variants based on its impr...