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Doravirine
go.drugbank.com/drugs/DB12301ApprovedInvestigational[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg). … treatments available for the management of HIV-1 infection.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: PİFELTRO 100 MG FİLM KAPLI TABLET, 30 ADETRuxolitinib
go.drugbank.com/drugs/DB08877ApprovedInvestigationalRuxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor. … It is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved in cytokine signalling and hematopoiesis.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: JAKAVI 20 MG (TABLETS), JAKAVI 20 MG TABLET, 168 TABLETFinerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigational[A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449] … Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: KERENDİA 20 MG FİLM KAPLI TABLET, 28 ADET, KERENDİA 20 MG FİLM KAPLI TABLET, 98 ADETSomatostatin
go.drugbank.com/drugs/DB09099ApprovedInvestigationalWithdrawnThe actions of somatostatin are mediated via signalling pathways of G protein-coupled somatostatin receptors. … Prosomastatin is further process into two active forms, somatostatin-14 (SST-14) and somatostatin-28 (SST-28), an extended SST-14 sequence to the N-terminus [A20384].
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsProducts: SOMATOSAN 3 MG IV INFUZYON ICIN 1 AMPUL, STILAMIN 3000 FOR INJECTION 3 mg/ampouleAlogliptin
go.drugbank.com/drugs/DB06203ApprovedInvestigationalFDA approved January 25, 2013. … Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4).
Mixtures: OSENI 25 MG/15 MG TABLETS, OSENI 25 MG/15 MG TABLETSCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesGonadorelin
go.drugbank.com/drugs/DB00644ApprovedInvestigationalVet approvedIt is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary.
Products: LH-RH FERRING 0,1 MG/ML IV ENJEKSIYONLUK COZELTI ICEREN AMPUL, 1 ADET, Kryptocur 0,2 mg/0,1 ml - nasale SprühlösungSodium oxybate
go.drugbank.com/drugs/DB09072ApprovedInvestigational[A18723] For safety reasons, sodium oxybate is a controlled substance only available through a restricted program in approved countries. … [L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter [A251445] and a metabolite of the inhibitory neurotransmitter GABA.
Products: Natriumoxybat Kalceks 500 mg/ml Lösung zum Einnehmen, Natriumoxybat neuraxpharm 500 mg/ml Lösung zum EinnehmenAcetyl-coenzyme A synthetase 2-like, mitochondrial
go.drugbank.com/bio_entities/BE0000746TargetHumansCatalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that ...
Polypeptides: Acetyl-coenzyme A synthetase 2-like, mitochondrialSynonyms: Acetate--CoA ligase 2, Acetyl-CoA synthetase 23-oxoacyl-[acyl-carrier-protein] synthase 2
go.drugbank.com/bio_entities/BE0000800TargetEscherichia coli (strain K12)Involved in the type II fatty acid elongation cycle (PubMed:6988423, PubMed:9013860). Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:22017312, PubMed:90138...
Polypeptides: 3-oxoacyl-[acyl-carrier-protein] synthase 2Low-density lipoprotein receptor-related protein 2
go.drugbank.com/bio_entities/BE0000942TargetTransporterHumansMediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity).
Polypeptides: Low-density lipoprotein receptor-related protein 2Synonyms: LRP-2