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Lumefantrine

Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plas...

Velaglucerase alfa

Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase.

Bafilomycin A1

The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. … This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

Sacrosidase

Treatment options for these patients are limited and usually consists of a lifelong sucrose-free diet; therefore, sacrosidase offers a potential alternative for symptom relief. … Sacrosidase is a liquid enzyme preparation from S.cerevisiae used for the treatment of congenital sucrose-isomaltase deficiency (CSID).

Nonoxynol-9

Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. … In several European countries, spermicides are no longer on the market.

Octylphenoxy polyethoxyethanol

Inecalcitol

Clioquinol

Clioquinol was withdrawn in 1983 due to neurotoxicity.

Zimelidine

Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving

Cyclandelate

A direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. … Cyclandelate is not approved for use in the U.S. or Canada, but is approved in various European countries.