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Ribociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalRibociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). … Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: KISQALI (200 MG), KISQALI 200 MG TABLETAS RECUBIERTASPegvisomant
go.drugbank.com/drugs/DB00082ApprovedInvestigationalPegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. … Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: SOMAVERT® 15 MG POLVO LIOFILIZADO PARA SOLUCIÓN INYECTABLE, SOMAVERT 15 MG ENJEKSIYONLUK COZELTI ICIN TOZ ICEREN FLAKON VE COZUCU, 30 ADETCabozantinib
go.drugbank.com/drugs/DB08875ApprovedInvestigationalCabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. … [L15123] In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and this same formulation gained additional approval in both the US and Canada in 2019
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexProducts: CABOMETYX 20 MG FİLM KAPLI TABLET, 30 ADET, CABOMETYX 40 MG FİLM KAPLI TABLET, 30 ADETZotepine
go.drugbank.com/drugs/DB09225ApprovedWithdrawnZotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA.
Categories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsProducts: ZOLEPTIL © 50 MG TABLETAS RECUBIERTAS.Midostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalIt was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108]. … Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 InducersSynonyms: 4'-N-benzoylstaurosporineStreptokinase
go.drugbank.com/drugs/DB00086ApprovedInvestigationalWithdrawnStreptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
Products: Streptokinase Karma 1 500 000 IU Powder for Solution for Infusion, KABIKINASE AMPOLLAS DE 750.000 UI POLVO PµRA INYECCIONTetrabenazine
go.drugbank.com/drugs/DB04844ApprovedIt is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. … A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one, 2-oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizineArmodafinil
go.drugbank.com/drugs/DB06413ApprovedInvestigational(a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007. … Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2B6 InducersSynonyms: (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide, R-modafinilLow- or Intermediate-1-risk Myelodysplastic Syndrome (MDS)
go.drugbank.com/conditions/DBCOND0043643Drugs: ImetelstatSynonyms: Low- or Intermediate-1-risk Myelodysplastic Syndrome (MDS)Carbamoylcholine
go.drugbank.com/drugs/DB00411ApprovedCarbamoylcholine, also known as carbachol, is a muscarinic agonist discovered in 1932. … [A226315] Carbamoylcholine was initially used as a treatment for migraines,[A226365] induction of diuresis,[A226370] and other parasympathetic effects.
Categories: Compounds used in a research, industrial, or household settingProducts: MIOSTAT %0.01 İNTRAOKÜLER ÇÖZELTİ (1 ADET), Isopto Carbachol 3%