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Clobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigationalClobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others. . Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesMefloquine
go.drugbank.com/drugs/DB00358ApprovedMalaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 ...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSulfadiazine
go.drugbank.com/drugs/DB00359ApprovedInvestigationalVet approvedOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Synonyms: N(1)-2-Pyrimidylsulfanilamide, N(1)-2-PyrimidinylsulfanilamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesVinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalVinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the trea...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsGrepafloxacin
go.drugbank.com/drugs/DB00365ApprovedWithdrawnGrepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for card...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProfenamine
go.drugbank.com/drugs/DB00392ApprovedProfenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada. In the US, the marketing of profen...
Synonyms: N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine, N,N-diethyl-α-methyl-10H-phenothiazine-10-ethanamineNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in sm...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesBeclomethasone dipropionate
go.drugbank.com/drugs/DB00394ApprovedInvestigationalBeclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to dexamethasone. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) ...
Mixtures: FORMODUAL N. 200/6UG, FORMODUAL N. 200/6UGCategories: P-glycoprotein inducers, P-glycoprotein substratesLoxapine
go.drugbank.com/drugs/DB00408ApprovedInvestigationalAn antipsychotic agent used in schizophrenia. [PubChem]
Categories: P-glycoprotein inhibitorsAcetohexamide
go.drugbank.com/drugs/DB00414ApprovedWithdrawnA sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Synonyms: N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea, 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates