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Displaying results 5531 - 5540 of 10000 in total
  1. Drug

    Ramosetron

    go.drugbank.com/drugs/DB09290
    Investigational

    Ramosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. … Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.

  2. Drug

    ACE393

    go.drugbank.com/drugs/DB05071
    Investigational

    ACE393 is an injectable vaccine designed to combat the bacterium Campylobacter jejuni, one of the greatest causes of bacterial diarrhoeal infections in the developed world.

  3. Drug

    Azelnidipine

    go.drugbank.com/drugs/DB09230
    Investigational

    It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unlike some other calcium channel blockers [L1379]. … Azelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan.

    International brands: Rezaltas LD
  4. Drug

    Gantenerumab

    go.drugbank.com/drugs/DB12034
    Investigational

    Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, with classical histopathological hallmarks including extracellular amyloid-beta (Aβ) plaques and intraneuronal neurofibrillary … [A244705, A244710, A244745] Gantenerumab is a fully human IgG1κ monoclonal antibody derived from the MorphoSys HuCAL®-Fab1 phage display library and subsequently optimized by _in vitro_ CDR cassette

  5. Drug

    TGAAC94

    go.drugbank.com/drugs/DB06175
    Investigational

    It was under investigation in clinical trials to treat Inflammatory Arthritis. In 2007, one patient participating in the clinical trial died and the trial was placed on clinical hold by the FDA. … tgAAC94 is a recombinant adeno-associated virus serotype 2 (AAV2) vector containing the cDNA for a human tumor necrosis factor receptor (TNFR)-immunoglobulin (IgG1) Fc fusion (TNFR:Fc) gene.

  6. Drug

    D-Serine

    go.drugbank.com/drugs/DB03929
    ApprovedInvestigationalWithdrawn

    A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.

    Synonyms: d-Serine
  7. Drug

    Cat dander extract

    go.drugbank.com/drugs/DB13904
    Approved

    It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats. … Cat dander extract can be used in immunotherapy in individuals who cannot avoid exposure to cat allergens to initiate hyposensitization.

  8. Drug

    Firocoxib

    go.drugbank.com/drugs/DB09217
    ExperimentalVet approved

    Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. … Firocoxib is not intended or approved for use in human medicine.

  9. Drug

    Lapretolimod

    go.drugbank.com/drugs/DB20120
    Investigational

    Lapretolimod is under investigation in clinical trial NCT03799510 (Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children). Lapretolimod has a monoisotopic molecular weight of 1745.28 Da. … Lapretolimod is a small molecule drug. The usage of the INN stem '-tolimod' in the name indicates that Lapretolimod is a toll-like receptor (TLR) agonist.

    Synonyms: Glucopyranosyl lipid a
  10. Drug

    AVI-4557

    go.drugbank.com/drugs/DB05447
    Experimental

    in clearance and an increase in maximal blood concentration (Cmax). … Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and longer availability of the drug in the patient's system through a decrease