D-Serine

DB03929ApprovedInvestigationalWithdrawnSmall molecule

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino...

Mechanism: Pharmacologically active on Glutamate receptor ionotropic, NMDA 1 and Glycine receptor subunit alpha-1
Curator reviewed
Formula / weight: C₃H₇NO₃ · 105.0926 g/mol (avg)
Code names: NSC-77689

Resolves to

Compound

UNII1K77H2Z9B1CAS312-84-5ChEMBLCHEMBL285123ChEBI35247PubChem71077KEGGC00740

Clinical / RWD

RxNorm1742747

Structure

InChIKeyMTCFGRXMJLQNBG-UWTATZPHSA-NSMILESN[C@H](CO)C(O)=O

Targets

Q05586GRIN1P23415GLRA1P29508SERPINB3P36275shp

Transporters

Q8TF71SLC16A10Q9UN76SLC6A14

What you can answer from here — as of September 12, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2TransportersSubstrate / inhibitor direction, not just membership

Listed above

18Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with D-Serine, and which of those have an active Phase 3 trial?

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