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Displaying results 5551 - 5560 of 8697 in total
  1. Drug

    4'-Methylene-5,8,10-trideazaaminopterin

    go.drugbank.com/drugs/DB05616
    Investigational

    It has been investigated for the treatment of Rheumatoid Arthritis (phase II). … CH-1504 is a an antirheumatic agent that has been shown in vitro to be a nonpolyglutamylatable and nonhydroxylatable antifolate that is more efficiently taken up into cells by the reduced folate carrier

  2. Target

    T-cell surface glycoprotein CD3 delta chain

    go.drugbank.com/bio_entities/BE0003456
    TargetHumans

    When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.

    Synonyms: T-cell receptor T3 delta chain
  3. Target

    T-cell surface glycoprotein CD3 gamma chain

    go.drugbank.com/bio_entities/BE0003457
    TargetHumans

    Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G … When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.

    Synonyms: T-cell receptor T3 gamma chain
  4. Target

    P2Y purinoceptor 4

    go.drugbank.com/bio_entities/BE0009822
    TargetHumans

    Receptor for UTP and UDP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

    Synonyms: Uridine nucleotide receptorFunction: G protein-coupled purinergic nucleotide receptor activity
  5. Drug

    Lucinactant

    go.drugbank.com/drugs/DB04897
    Approved

    Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. … It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P).

  6. Drug

    Stepronin

    go.drugbank.com/drugs/DB01423
    Experimental

    Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of muc...

  7. Drug

    Phloxine B

    go.drugbank.com/drugs/DB13911
    ApprovedWithdrawn

    Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A Inhibitors
  8. Drug

    Gadopiclenol

    go.drugbank.com/drugs/DB17084
    ApprovedInvestigational

    The product label includes a black box warning regarding the increased risk for NSF among patients with impaired elimination of the drugs.[L43817] … It is indicated for use with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and the body.

  9. Drug

    Eprodisate

    go.drugbank.com/drugs/DB06405
    Investigational

    Eprodisate slows the decline of renal function in AA amyloidosis.

  10. Drug

    Oxantel

    go.drugbank.com/drugs/DB13670
    Investigational

    Oxantel is an anthelmintic drug that targets parasitic acetylcholine receptors.[A275093, A275098]