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Pentamidine
go.drugbank.com/drugs/DB00738ApprovedInvestigationalIt may cause diabetes mellitus, central nervous system damage, and other toxic effects. … Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: p,p'-(pentamethylenedioxy)dibenzamidine, 1,5-bis(4-amidinophenoxy)pentaneBoceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnBoceprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) do not reccomend Boceprevir in combination
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)Polymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429]. … Polymyxin B was discovered in the 1940s[A176429]. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes[A176426].
Synonyms: Polymyxin B, Polimixina BInternational brands: Polomyxin BIsavuconazole
go.drugbank.com/drugs/DB11633ApprovedInvestigationalhas a potential for nephrotoxicity [A32029]. … It is proposed that the intravenous and oral dosing can be used interchangeably [L1482], without the need for a repeat loading dose when transitioning from an IV to an oral formulation [A32026].
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: CRESEMBA (100 MG HARD CAPSULES), CRESEMBA (POWDER FOR SOLUTION FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200 MG/VIAL)Pivmecillinam
go.drugbank.com/drugs/DB01605ApprovedInvestigationalPivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. … It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Categories: Heterocyclic Compounds, 2-RingProducts: Selexid 200 mg Filmtabletten, Selexid 400 mg film-coated tabletsMinocycline
go.drugbank.com/drugs/DB01017ApprovedInvestigationalMinocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. … [A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamideProducts: XELTETRA-M, Udima 50 mg - KapselnHydrogen peroxide
go.drugbank.com/drugs/DB11091ApprovedInvestigationalVet approvedIt is used in industrial and cosmetic applications as a bleaching agent. … Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution.
Mixtures: K-100, K-100Categories: Compounds used in a research, industrial, or household setting1-aminocyclopropane-1-carboxylate synthase-like protein 1
go.drugbank.com/bio_entities/BE0003515TargetHumansDoes not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine
Polypeptides: 1-aminocyclopropane-1-carboxylate synthase-like protein 1Synonyms: ACC synthase-like protein 1Cloxazolam
go.drugbank.com/drugs/DB01553ExperimentalAs well, it has also been studied in Japan in doses of 15-30mg/day as an adjunct in the treatment of intractable epilepsy, for which it has demonstrated effectiveness. … Cloxazolam is a benzodiazepine with anxiolytic, sedative/hypnotic, muscle relaxant, and antiepileptic effects.
Categories: Heterocyclic Compounds, 2-RingProducts: OLCADIL ® 1 MG COMPRIMIDOS, OLCADIL ® 2 MG COMPRIMIDOSWheat
go.drugbank.com/drugs/DB10579ApprovedWheat allergenic extract is used in allergenic testing.
Mixtures: ITALDERMOL G, FITO INTERTULLE, 5 ADETProducts: FITO % 5 KREM, 10 G, FITO % 5 KREM, 20 G